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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 10 — Apr. 1, 2005
  • pp: 1917–1933

Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model

Jarod C. Finlay and Thomas H. Foster  »View Author Affiliations


Applied Optics, Vol. 44, Issue 10, pp. 1917-1933 (2005)
http://dx.doi.org/10.1364/AO.44.001917


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Abstract

We present two forward-adjoint models for recovering intrinsic fluorescence spectra and hemoglobin oxygen saturation of turbid samples. The first fits measured diffuse reflectance spectra to obtain the absorption and scattering spectra of the medium, and these are then used to correct distortions imposed on the fluorescence spectrum by absorption and scattering. The second fits only the measured fluorescence spectrum to determine simultaneously the amplitudes of absorption and fluorescence basis spectra and scattering parameters. Both methods are validated with Monte Carlo simulations and experimentally in scattering phantoms containing nicotinamide adenine dinucleotide and human erythrocytes. Preliminary measurements from murine tumors in vivo are presented.

© 2005 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

History
Original Manuscript: July 26, 2004
Revised Manuscript: August 25, 2004
Manuscript Accepted: October 22, 2004
Published: April 1, 2005

Citation
Jarod C. Finlay and Thomas H. Foster, "Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model," Appl. Opt. 44, 1917-1933 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-10-1917

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