Simulations based on diffusion theory that use a finite-element method and rely on an magnetic resonance imaging head model suggest that time-resolved diffuse optical techniques could provide information about the depth at which variations in perfusion take place and improve the detection of cortical activation. Experimental investigations were performed with sequentially driven picosecond laser diodes and an eight-channel time-correlated single-photon-counting detection system. The experimental results obtained for activation in the motor cortex, and for the Valsalva maneuver, confirm our assumptions and are in good agreement with the simulated data.
© 2005 Optical Society of America
Original Manuscript: July 19, 2004
Revised Manuscript: November 9, 2004
Manuscript Accepted: December 5, 2004
Published: April 1, 2005
Bruno Montcel, Renee Chabrier, and Patrick Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl. Opt. 44, 1942-1947 (2005)