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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 44, Iss. 5 — Feb. 10, 2005
  • pp: 770–775

Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography

Geng Ku, Xueding Wang, Xueyi Xie, George Stoica, and Lihong V. Wang  »View Author Affiliations


Applied Optics, Vol. 44, Issue 5, pp. 770-775 (2005)
http://dx.doi.org/10.1364/AO.44.000770


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Abstract

Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.

© 2005 Optical Society of America

History
Original Manuscript: July 19, 2004
Revised Manuscript: October 7, 2004
Manuscript Accepted: October 20, 2004
Published: February 10, 2005

Citation
Geng Ku, Xueding Wang, Xueyi Xie, George Stoica, and Lihong V. Wang, "Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography," Appl. Opt. 44, 770-775 (2005)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-44-5-770


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References

  1. S. L. Jacques, S. A. Prahl, “Absorption spectra for biological tissues,” (Oregon Medical Laser Center, Portland, Oreg., 2004), http://omlc.ogi.edu/classroom/ece532/class3/muaspectra.html .
  2. H. Maeda, “The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting,” Adv. Enzyme Regul. 41, 189–207 (2001). [CrossRef] [PubMed]
  3. A. A. Karabutov, E. V. Savateeva, N. B. Podymova, A. A. Oraevsky, “Backward mode detection of laser-induced wideband ultrasonic transients with optoacoustic transducer,” J. Appl. Phys. 87, 2003–2014 (2000). [CrossRef]
  4. A. A. Karabutov, E. V. Savateeva, A. A. Oraevsky, “Imaging of layered structures in biological tissues with optoacoustic front surface transducer,” in Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, S. L. Jacques, G. J. Mueller, A. Roggan, D. H. Sliney, eds., Proc SPIE3601, 284–295 (1999).
  5. C. G. A. Hoelen, F. F. M. de Mul, “Image reconstruction for photoacoustic scanning of tissue structures,” Appl. Opt. 39, 5872–5883 (2000). [CrossRef]
  6. G. Ku, L.-H. V. Wang, “Scanning thermoacoustic tomography in biological tissue,” Med. Phys. 27, 1195–1202 (2000). [CrossRef] [PubMed]
  7. G. Ku, L.-H. V. Wang, “Scanning microwave-induced thermoacoustic tomography: signal, resolution, and contrast,” Med. Phys. 28, 4–10 (2001). [CrossRef] [PubMed]
  8. R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen, T. G. van Leeuwen, “Photoacoustic determination of blood vessel diameter,” Phys. Med. Biol. 49, 4745–4756 (2004). [CrossRef] [PubMed]
  9. R. O. Esenaliev, A. A. Karabutov, A. A. Oraevsky, “Sensitivity of laser optoacoustic imaging in detection of small deeply embedded tumors,” IEEE J. Sel. Top. Quantum Electron. 5, 981–988 (1999). [CrossRef]
  10. A. A. Oraevsky, E. V. Savateeva, S. V. Solomatin, A. A. Karabutov, V. G. Andreev, Z. Gatalica, T. Khamapirad, P. M. Henrichs, “Optoacoustic imaging of blood for visualization and diagnostics of breast cancer,” in Biomedical Optoacoustics III, A. A. Oraevsky, ed., Proc. SPIE4618, 81–92 (2002). [CrossRef]
  11. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, L.-H. V. Wang, “Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo,” Nat. Biotechnol. 21, 803–806 (2003). [CrossRef] [PubMed]
  12. X. Wang, G. Ku, M. A. Wegiel, D. J. Bornhop, G. Stoica, L.-H. V. Wang, “Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent,” Opt. Lett. 29, 730–732 (2004). [CrossRef] [PubMed]
  13. G. Ku, X. Wang, X. Xie, G. Stoica, L.-H. V. Wang, “Multiple-bandwidth photoacoustic tomography,” Phys. Med. Biol. 49, 1329–1338 (2004). [CrossRef] [PubMed]
  14. F. Judah, “Angiogenesis in cancer, vascular, rheumatoid and other disease,” Nat. Med. (N.Y.) 1, 27–31 (1995). [CrossRef]
  15. P. Carmeliet, K. Rakesh, R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407, 249–257 (2000). [CrossRef] [PubMed]
  16. F. Judah, “Role of angiogenesis in tumor growth and metastasis,” Semin. Oncol. 29, 15–18 (2002).
  17. American National Standards Institute, American National Standard for the Safe Use of Lasers ANSI Z136.1-2000 (American National Standards Institute, New York, 2000).
  18. G. D. Hall, G. Stoica, “Characterization of brain and bone-metastasizing clones selected from an ethylnitrosourea-induced rat mammary carcinoma,” Clin. Exp. Metast. 12, 283–295 (1994). [CrossRef]
  19. H. Maeda, “The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting,” Adv. Enzyme Regul. 41, 189–207 (2001). [CrossRef] [PubMed]
  20. H. Maeda, J. Fang, T. Inutsuka, Y. Kitamoto, “Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications,” Int. Immunopharmacol. 3, 319–328 (2003). [CrossRef] [PubMed]

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