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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 10 — Apr. 1, 2007
  • pp: 1742–1753

Empirical model functions to calculate hematocrit-dependent optical properties of human blood

Martina Meinke, Gerhard Müller, Jürgen Helfmann, and Moritz Friebel  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1742-1753 (2007)
http://dx.doi.org/10.1364/AO.46.001742


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Abstract

The absorption coefficient, scattering coefficient, and effective scattering phase function of human red blood cells (RBCs) in saline solution were determined for eight different hematocrits (Hcts) between 0.84% and 42.1% in the wavelength range of 250-1100 nm using integrating sphere measurements and inverse Monte Carlo simulation. To allow for biological variability, averaged optical parameters were determined under flow conditions for ten different human blood samples. Based on this standard blood, empirical model functions are presented for the calculation of Hct-dependent optical properties for the RBCs. Changes in the optical properties when saline solution is replaced by blood plasma as the suspension medium were also investigated.

© 2007 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(290.5820) Scattering : Scattering measurements
(290.7050) Scattering : Turbid media
(300.1030) Spectroscopy : Absorption

ToC Category:
Optical spectroscopic imaging and diagnostics

History
Original Manuscript: June 15, 2006
Revised Manuscript: September 28, 2006
Manuscript Accepted: October 16, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Martina Meinke, Gerhard Müller, Jürgen Helfmann, and Moritz Friebel, "Empirical model functions to calculate hematocrit-dependent optical properties of human blood," Appl. Opt. 46, 1742-1753 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-10-1742

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