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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 14 — May. 10, 2007
  • pp: 2778–2784

Tomographic bioluminescence imaging with varying boundary conditions

Vadim Y. Soloviev  »View Author Affiliations


Applied Optics, Vol. 46, Issue 14, pp. 2778-2784 (2007)
http://dx.doi.org/10.1364/AO.46.002778


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Abstract

Three-dimensional bioluminescence imaging is an emerging technique that can be used to monitor molecular events in intact living systems. The inverse problem of 3D bioluminescence imaging does not have a unique solution because it requires reconstruction of a 3D source function from a 2D one. A novel approach that addresses this problem with the aid of a simple experimental setup and solves the uniqueness problem of the solution for a monochromatic measurement set is suggested here. The approach is verified numerically by reconstructing bioluminescent objects of various shapes embedded inside highly scattering media, such as biologiçal tissue.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 10, 2006
Revised Manuscript: October 13, 2006
Manuscript Accepted: December 28, 2006
Published: April 23, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Vadim Y. Soloviev, "Tomographic bioluminescence imaging with varying boundary conditions," Appl. Opt. 46, 2778-2784 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-14-2778

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