OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 22 — Aug. 1, 2007
  • pp: 5340–5346

Contrast-enhanced imaging of cerebral vasculature with laser speckle

K. Murari, N. Li, A. Rege, X. Jia, A. All, and N. Thakor  »View Author Affiliations


Applied Optics, Vol. 46, Issue 22, pp. 5340-5346 (2007)
http://dx.doi.org/10.1364/AO.46.005340


View Full Text Article

Enhanced HTML    Acrobat PDF (2310 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

High-resolution cerebral vasculature imaging has applications ranging from intraoperative procedures to basic neuroscience research. Laser speckle, with spatial contrast processing, has recently been used to map cerebral blood flow. We present an application of the technique using temporal contrast processing to image cerebral vascular structures with a field of view a few millimeters across and approximately 20   μm resolution through a thinned skull. We validate the images using fluorescent imaging and demonstrate a factor of 2–4 enhancement in contrast-to-noise ratios over reflectance imaging using white or spectrally filtered green light. The contrast enhancement enables the perception of approximately 10%–30% more vascular structures without the introduction of any contrast agent.

© 2007 Optical Society of America

OCIS Codes
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 2, 2007
Manuscript Accepted: May 8, 2007
Published: July 12, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
K. Murari, N. Li, A. Rege, X. Jia, A. All, and N. Thakor, "Contrast-enhanced imaging of cerebral vasculature with laser speckle," Appl. Opt. 46, 5340-5346 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-22-5340

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited