OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: James C. Wyant
  • Vol. 46, Iss. 33 — Nov. 20, 2007
  • pp: 8068–8073

Improving the sensitivity limit of surface plasmon resonance biosensors by detecting mixed interference signals

W. Yuan, H. P. Ho, Y. K. Suen, S. K. Kong, and Chinlon Lin  »View Author Affiliations


Applied Optics, Vol. 46, Issue 33, pp. 8068-8073 (2007)
http://dx.doi.org/10.1364/AO.46.008068


View Full Text Article

Enhanced HTML    Acrobat PDF (667 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We demonstrate that the sensitivity limit of intensity-based surface plasmon resonance (SPR) biosensors can be enhanced when we combine the effects of the phase and amplitude contributions instead of detecting the amplitude variation only. Experimental results indicate that an enhancement factor of as much as 20 times is achievable, yet with no compromise in measurement dynamic range. While existing SPR biosensor systems are predominantly based on the angular scheme, which relies on detecting intensity variations associated with amplitude changes only, the proposed scheme may serve as a direct system upgrade approach for these systems. The new measurement scheme may therefore lead to a strong impact in the design of SPR biosensors.

© 2007 Optical Society of America

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(240.6690) Optics at surfaces : Surface waves

ToC Category:
Remote Sensing and Sensors

History
Original Manuscript: July 5, 2007
Revised Manuscript: August 27, 2007
Manuscript Accepted: September 17, 2007
Published: November 19, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
W. Yuan, H. P. Ho, Y. K. Suen, S. K. Kong, and Chinlon Lin, "Improving the sensitivity limit of surface plasmon resonance biosensors by detecting mixed interference signals," Appl. Opt. 46, 8068-8073 (2007)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-33-8068


Sort:  Year  |  Journal  |  Reset  

References

  1. R. L. Rich and D. G. Myszka, "Survey of the year 2004 commercial optical biosensor literature," J. Mol. Recognit. 18, 431-478 (2005). [CrossRef] [PubMed]
  2. W. Lukosz, "Principle and sensitivities of integrated optical and surface plasmon sensors for direct affinity sensing and immunosensing," Biosens. Bioelectron. 6, 215-225 (1991). [CrossRef]
  3. R. McKendry, J. Zhang, Y. Arntz, T. Strunz, M. Hegner, H. P. Lang, M. K. Baller, U. Certa, E. Meyer, H. Guntherodt, and C. Gerber, "Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array," Proc. Natl. Acad. Sci. U.S.A. 99, 9783-9788 (2002). [CrossRef] [PubMed]
  4. H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, 1988), Chap. 2.
  5. J. Homola, Surface Plasmon Resonance Based Sensors (Springer-Verlag, 2006). [CrossRef]
  6. S. Y. Wu, H. P. Ho, W. C. Law, and C. L. Lin, "Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration," Opt. Lett. 29, 2378-2380 (2004). [CrossRef] [PubMed]
  7. Y.-D. Su, S.-J. Chen, and T.-L. Yeh, "Common-path phase-shift interferometry surface plasmon resonance imaging system," Opt. Lett. 30, 1488-1490 (2005). [CrossRef] [PubMed]
  8. C. Chou, H. T. Wu, Y. C. Huang, and Y. L. Chen, "Characteristics of a paired surface plasma waves biosensor," Opt. Express 14, 4307-4315 (2006). [CrossRef] [PubMed]
  9. W.-C. Kuo, C. Chou, and H.-T. Wu, "Optical heterodyne surface-plasmon resonance biosensor," Opt. Lett. 28, 1329-1331 (2003). [CrossRef] [PubMed]
  10. M.-H. Chiu, S.-F. Wang, and R.-S. Chang, "D-type fiber biosensor based on surface-plasmon resonance technology and heterodyne interferometry," Opt. Lett. 30, 233-235 (2005). [CrossRef] [PubMed]
  11. F. C. Chien and S. J. Chen, "A sensitivity comparison of optical biosensor based on four different surface plasmon resonance modes," Biosens. Bioelectron. 20, 633-642 (2004). [CrossRef] [PubMed]
  12. X. Yao, X. Li, F. Toledo, C. Zurita-Lopez, M. Gutova, J. Momand, and F. Zhou, "Sub-attomole oligonucleotide and p53 cDNA determinations via a high-resolution surface plasmon resonance combined with oligonucleotide-capped gold nanoparticle signal amplification," Anal. Chem. 354, 220-228 (2006).
  13. H. P. Ho, W. C. Law, S. Y. Wu, X. H. Liu, S. P. Wong, C. Lin, and S. K. Kong, "Surface plasmon resonance biosensor based on measuring low-level birefringence using a photoelastic modulation technique," Sens. Actuators B 114, 80-84 (2006). [CrossRef]
  14. P. P. Markowicz, W. C. Law, A. Baev, P. N. Prasad, S. Patskovsky, and A. V. Kabashin, "Phase-sensitive time-modulated surface plasmon resonance polarimetry for wide dynamic range biosensing," Opt. Express 15, 1745-1754 (2007). [CrossRef] [PubMed]
  15. B. Ran and S. G. Lipson, "Comparison between sensitivities of phase and intensity detection in surface plasmon resonance," Opt. Express 14, 5641-5650 (2006). [CrossRef] [PubMed]
  16. J. Homala, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors review," Sens. Actuators B 54, 3-15 (1999). [CrossRef]
  17. S. Ferretti, S. Paynter, D. A. Russell, and K. E. Sapsford, "Self-assembled monolayers: a versatile tool for the formation of bio-surfaces," Trends Anal. Chem. 19, 530-540 (2000). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited