Abstract
A laser spectroscopic system based on a cw difference-frequency generation source with a ratiometric multipass absorption detection scheme was employed for high-resolution spectroscopic investigation of gas-phase monomethylamine (MMA), dimethylamine (DMA), and trimethylamine (TMA). Possible application of the system as a noninvasive human breath analyzer for renal and liver diseases is targeted. The system operates in the fundamental stretch absorption region around . A detection sensitivity of (for signal-to-noise ratio ) is achieved, corresponding to detection limits of (parts in ) for MMA, for DMA, and for TMA in mixtures containing and with concentrations of up to those present in human breath (2% and 5%, respectively). Future developments are discussed to further improve these detection limits that are currently still about 2 orders of magnitude higher than required for direct methylamine monitoring in human breath.
© 2008 Optical Society of America
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