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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 48, Iss. 10 — Apr. 1, 2009
  • pp: D262–D272

Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents

Scott C. Davis, Brian W. Pogue, Hamid Dehghani, and Keith D. Paulsen  »View Author Affiliations


Applied Optics, Vol. 48, Issue 10, pp. D262-D272 (2009)
http://dx.doi.org/10.1364/AO.48.00D262


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Abstract

The measurement sensitivities of absorbing and fluorescing objects in tissue are compared to determine conditions for which fluorescence data are favorable over those derived from absorption. A simulated human breast volume was used to model the relative perturbation in boundary data caused by a deeply embedded anomaly containing elevated concentrations of theoretical exogenous contrast agents with absorption properties resembling lutetium texaphyrin (LuTex) and Indocyanine Green (ICG). Synthetic data were used to produce quantum yield values representing the transition between conditions favorable to fluorescence versus absorption imaging. The parameters explored include tumor-to-background contrast, background drug concentration, and excitation light filtering efficiency. Drug concentration in the background was the primary factor that determined which contrast mechanism provided the more sensitive measurements. Specifically, fluorescence measurements are favorable if background drug concentrations are below 135 200 nM for LuTex and 25 50 nM for ICG, while absorption measurements are more sensitive above these ranges.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media

History
Original Manuscript: September 5, 2008
Revised Manuscript: January 20, 2009
Manuscript Accepted: January 23, 2009
Published: March 12, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Scott C. Davis, Brian W. Pogue, Hamid Dehghani, and Keith D. Paulsen, "Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents," Appl. Opt. 48, D262-D272 (2009)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-48-10-D262

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