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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 16 — Jun. 1, 2010
  • pp: 3035–3041

Biolistic injection of microparticles with high-power Nd:YAG laser

Tae-hee Han, Ardian B. Gojani, and Jack J. Yoh  »View Author Affiliations


Applied Optics, Vol. 49, Issue 16, pp. 3035-3041 (2010)
http://dx.doi.org/10.1364/AO.49.003035


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Abstract

Irradiation of a high-power laser pulse (above 10 9 W / cm 2 ) on thin metal foil causes ablation, which is characterized by a strong plasma-shock formation followed by a rapid expulsion of surface matter. The shock propagates through the foil and reverberates on the rear side causing instant deformation of the metal foil, whose surface is treated with microparticles prior to ablation. Based on this principle of microparticle ejection, we develop a laser-based injector that features controllability and stability. We also perform characterization of the penetration depths at varying confinements and energy levels. The confinement media include glass (BK7), water, and ultrasound gel. Biological tissue was replicated by a gelatin–water solution at a 3% weight ratio. Present data show that the confinement effect results in a significant enhancement of penetration depth reached by 5 μm cobalt microparticles. Also, there exists an optimal thickness at each energy level when using liquid confinement for enhanced particle delivery.

© 2010 Optical Society of America

OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(140.3440) Lasers and laser optics : Laser-induced breakdown
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(140.3538) Lasers and laser optics : Lasers, pulsed

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 9, 2009
Revised Manuscript: April 6, 2010
Manuscript Accepted: April 30, 2010
Published: May 25, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Tae-hee Han, Ardian B. Gojani, and Jack J. Yoh, "Biolistic injection of microparticles with high-power Nd:YAG laser," Appl. Opt. 49, 3035-3041 (2010)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-49-16-3035


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