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Applied Optics

Applied Optics


  • Editor: Joseph N. Mait
  • Vol. 49, Iss. 26 — Sep. 10, 2010
  • pp: 4921–4925

Nanoparticle detection using dual-phase interferometry

Bradley Deutsch, Ryan Beams, and Lukas Novotny  »View Author Affiliations

Applied Optics, Vol. 49, Issue 26, pp. 4921-4925 (2010)

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The detection and identification of nanoparticles is of growing interest in atmospheric monitoring, medicine, and semiconductor manufacturing. While elastic light scattering with interferometric detection provides good sensitivity to single particles, active optical components prevent scalability of realistic sizes for deployment in the field or clinic. Here, we report on a simple phase-sensitive nanoparticle detection scheme with no active optical elements. Two measurements are taken simultaneously, allowing the amplitude and phase to be decoupled. We demonstrate the detection of 25 nm Au particles in liquid in Δ t 1 ms with a signal-to-noise ratio of 37 . Such performance makes it possible to detect nanoscale contaminants or larger proteins in real time without the need of artificial labeling.

© 2010 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(290.5850) Scattering : Scattering, particles

ToC Category:
Instrumentation, Measurement, and Metrology

Original Manuscript: May 28, 2010
Manuscript Accepted: August 2, 2010
Published: September 8, 2010

Virtual Issues
Vol. 5, Iss. 13 Virtual Journal for Biomedical Optics

Bradley Deutsch, Ryan Beams, and Lukas Novotny, "Nanoparticle detection using dual-phase interferometry," Appl. Opt. 49, 4921-4925 (2010)

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