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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 50, Iss. 10 — Apr. 1, 2011
  • pp: 1389–1395

Early detection of liver cancer based on bioluminescence tomography

Xibo Ma, Jie Tian, Chenghu Qin, Xin Yang, Bo Zhang, Zhenwen Xue, Xing Zhang, Dong Han, Di Dong, and Xueyan Liu  »View Author Affiliations


Applied Optics, Vol. 50, Issue 10, pp. 1389-1395 (2011)
http://dx.doi.org/10.1364/AO.50.001389


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Abstract

As a new modality of molecular imaging, bioluminescence imaging has been widely used in tumor detection and drug evaluation. However, BLI cannot present the depth of information for internal diseases such as a liver tumor in situ or a lung tumor in situ. In this paper, we describe a bioluminescence tomography (BLT) method based on the bioluminescent intensity attenuation calibration and applied it to the early detection of liver cancer in situ. In comparison with BLT without calibration, this method could improve the reconstruction accuracy by more than 10%. In comparison with micro-computed tomography and other traditional imaging modalities, this method can detect a liver tumor at a very early stage and provide reliable location information.

© 2011 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1420) Medical optics and biotechnology : Biology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 14, 2010
Revised Manuscript: January 28, 2011
Manuscript Accepted: January 28, 2011
Published: March 28, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Xibo Ma, Jie Tian, Chenghu Qin, Xin Yang, Bo Zhang, Zhenwen Xue, Xing Zhang, Dong Han, Di Dong, and Xueyan Liu, "Early detection of liver cancer based on bioluminescence tomography," Appl. Opt. 50, 1389-1395 (2011)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-50-10-1389


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