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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 50, Iss. 21 — Jul. 20, 2011
  • pp: 4237–4245

Hybrid diffusion and two-flux approximation for multilayered tissue light propagation modeling

Dmitry Yudovsky and Anthony J. Durkin  »View Author Affiliations


Applied Optics, Vol. 50, Issue 21, pp. 4237-4245 (2011)
http://dx.doi.org/10.1364/AO.50.004237


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Abstract

Accurate and rapid estimation of fluence, reflectance, and absorbance in multilayered biological media has been essential in many biophotonics applications that aim to diagnose, cure, or model in vivo tissue. The radiative transfer equation (RTE) rigorously models light transfer in absorbing and scattering media. However, analytical solutions to the RTE are limited even in simple homogeneous or plane media. Monte Carlo simulation has been used extensively to solve the RTE. However, Monte Carlo simulation is computationally intensive and may not be practical for applications that demand real-time results. Instead, the diffusion approximation has been shown to provide accurate estimates of light transport in strongly scattering tissue. The diffusion approximation is a greatly simplified model and produces analytical solutions for the reflectance and absorbance in tissue. However, the diffusion approximation breaks down if tissue is strongly absorbing, which is common in the visible part of the spectrum or in applications that involve darkly pigmented skin and/or high local volumes of blood such as port-wine stain therapy or reconstructive flap monitoring. In these cases, a model of light transfer that can accommodate both strongly and weakly absorbing regimes is required. Here we present a model of light transfer through layered biological media that represents skin with two strongly scattering and one strongly absorbing layer.

© 2011 Optical Society of America

OCIS Codes
(000.4430) General : Numerical approximation and analysis
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.7050) Medical optics and biotechnology : Turbid media
(230.4170) Optical devices : Multilayers
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 12, 2011
Revised Manuscript: June 3, 2011
Manuscript Accepted: June 18, 2011
Published: July 19, 2011

Virtual Issues
Vol. 6, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Dmitry Yudovsky and Anthony J. Durkin, "Hybrid diffusion and two-flux approximation for multilayered tissue light propagation modeling," Appl. Opt. 50, 4237-4245 (2011)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-50-21-4237


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