OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Editor: Joseph N. Mait
  • Vol. 52, Iss. 33 — Nov. 20, 2013
  • pp: 8060–8066

Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies

Manuela Roman, Jean Gonzalez, Jennifer Carrasquilla, Sarah J. Erickson, Rad Akhter, and Anuradha Godavarty  »View Author Affiliations


Applied Optics, Vol. 52, Issue 33, pp. 8060-8066 (2013)
http://dx.doi.org/10.1364/AO.52.008060


View Full Text Article

Enhanced HTML    Acrobat PDF (1122 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A generation-2 (Gen-2) handheld optical imager capable of two-dimensional surface and three-dimensional tomographic imaging has recently been developed. Herein, the ability of the handheld imager to detect and resolve two targets under diffuse and fluorescence imaging conditions has been demonstrated via tissue phantom studies. Two-dimensional surface imaging studies demonstrated that two 0.96 cm diameter Indocyannine Green targets were detected and resolved 0.5cm apart (between edges) at a target depth of 1 cm during diffuse imaging and up to 2 cm depth during fluorescence imaging. Preliminary 3D tomographic imaging capability to resolve the two targets was also demonstrated, but requires extensive future studies.

© 2013 Optical Society of America

OCIS Codes
(110.3080) Imaging systems : Infrared imaging
(170.0110) Medical optics and biotechnology : Imaging systems
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Imaging Systems

History
Original Manuscript: May 9, 2013
Revised Manuscript: October 8, 2013
Manuscript Accepted: October 22, 2013
Published: November 15, 2013

Virtual Issues
Vol. 9, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Manuela Roman, Jean Gonzalez, Jennifer Carrasquilla, Sarah J. Erickson, Rad Akhter, and Anuradha Godavarty, "Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies," Appl. Opt. 52, 8060-8066 (2013)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-52-33-8060


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. S. J. Erickson and A. Godavarty, “Hand-held based near-infrared optical imaging systems: a review,” Med. Eng. Phys. 31, 495–509 (2009). [CrossRef]
  2. S. J. Erickson, A. Godavarty, S. L. Martinez, J. Gonzalez, A. Romero, M. Roman, A. Nunez, J. Ge, S. Regalado, R. Kiszonas, and C. Lopez-Penalver, “Hand-held optical devices for breast cancer: spectroscopic and 3D tomographic imaging,” IEEE J. Sel. Top. Quantum Electron. 18, 1298–1312 (2012). [CrossRef]
  3. J. Gonzalez, J. DeCerce, S. J. Erickson, S. L. Martinez, A. Nunez, M. Roman, B. Traub, C. Flores, S. Roberts, E. Hernandez, W. Aguirre, R. Kiszonas, and A. Godavarty, “Hand-held optical imager (Gen-2): improved instrumentation and target detectability,” J. Biomed. Opt. 17, 081402 (2012). [CrossRef]
  4. J. Gonzalez, M. Roman, M. Hall, and A. Godavarty, “Gen-2 hand-held optical imager towards cancer imaging: reflectance and transillumination phantom studies,” Sensors 12, 1885–1897 (2012). [CrossRef]
  5. L. V. Wang and H. Wu, Biomedical Optics: Principles and Imaging (Wiley, 2007).
  6. V. C. Kavuri, Z. Lin, F. Tian, and H. Liu, “Sparsity enhanced spatial resolution and depth localization in diffuse optical tomography,” Biomed. Opt. Express 3, 943 (2012). [CrossRef]
  7. H. Niu, Z. Lin, F. Tian, S. Dhamne, and H. Liu, “Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm,” J. Biomed. Opt. 15, 046005 (2010). [CrossRef]
  8. J. Yang, T. Zhang, H. Yang, and H. Jiang, “Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics,” Appl. Opt. 51, 3461–3469 (2012). [CrossRef]
  9. J. Chen, V. Venugopal, F. Lesage, and X. Intes, “Time-resolved diffuse optical tomography with patterned-light illumination and detection,” Opt. Lett. 35, 2121–2123 (2010). [CrossRef]
  10. X. Liu, W. Daifa, F. Liu, and J. Bai, “Principal component analysis of dynamic fluorescence diffuse optical tomography images,” Opt. Express 18, 6300–6314 (2010). [CrossRef]
  11. F. Gao, J. Li, L. Zhang, P. Poulet, H. Zhao, and Y. Yamada, “Simultaneous fluorescence yield and lifetime tomography from time-resolved transmittances of small-animal-size phantom,” Appl. Opt. 49, 3163–3172 (2010). [CrossRef]
  12. Q. Zhang, L. Yin, Y. Tan, Z. Yuan, and H. Jiang, “Quantitative bioluminescence tomography guided by diffuse optical tomography,” Opt. Express 16, 1481–1486 (2008). [CrossRef]
  13. J. Ge, B. Zhu, S. Regalado, and A. Godavarty, “Three-dimensional fluorescence-enhanced optical tomography using a hand-held probe based imaging system,” Med. Phys. 35, 3354–3363 (2008). [CrossRef]
  14. A. Godavarty, M. J. Eppstein, C. Zhang, S. Theru, A. B. Thompson, M. Gurfinkel, and E. M. Sevick-Muraca, “Fluorescence-enhanced optical imaging in large tissue volumes using a gain modulated ICCD camera,” Phys. Med. Biol. 48, 1701–1720 (2003). [CrossRef]
  15. M. J. Eppstein, D. J. D. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, “Three-dimensional near-infrared fluorescence tomography with Bayesian methodologies for image reconstruction from sparse and noisy data sets,” Proc. Natl. Acad. Sci. USA 99, 9619–9624 (2002).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 
Fig. 4.
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited