Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue. Here we present a combined optical-resolution PAM (ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection. The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT.
© 2013 Optical Society of America
Original Manuscript: January 9, 2013
Revised Manuscript: February 17, 2013
Manuscript Accepted: February 21, 2013
Published: March 14, 2013
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics
Lei Xi, Can Duan, Huikai Xie, and Huabei Jiang, "Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivomicrocirculation study," Appl. Opt. 52, 1928-1931 (2013)