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Applied Optics

Applied Optics


  • Vol. 24, Iss. 23 — Dec. 1, 1985
  • pp: 3958–3968

Nuclear magnetic resonance imaging

William P. Rothwell  »View Author Affiliations

Applied Optics, Vol. 24, Issue 23, pp. 3958-3968 (1985)

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Nuclear magnetic resonance imaging (NMRI) is a powerful imaging modality having a range of important applications to medicine and industry. The basic principles of NMRI are reviewed in this paper. Particular emphasis is placed on developing the conceptual and mathematical basis for understanding three fundamental NMRI concepts, namely, spin density projection, phase encoding, and selective irradiation. The question of resolution in NMR imaging is discussed, and a brief presentation of chemical shift, spin relaxation time, and fluid flow velocity imaging is given.

© 1985 Optical Society of America

Original Manuscript: October 2, 1984
Published: December 1, 1985

William P. Rothwell, "Nuclear magnetic resonance imaging," Appl. Opt. 24, 3958-3968 (1985)

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  1. E. M. Purcell, H. C. Torrey, R. V. Pound, “Resonance Absorption by Nuclear Magnetic Moments in a Solid,” Phys. Rev. 69, 37 (1946). [CrossRef]
  2. F. Bloch, W. W. Hansen, M. Packard, “Nuclear Induction,” Phys. Rev. 69, 127 (1946). [CrossRef]
  3. E. D. Becker, High Resolution NMR: Theory and Chemical Applications (Academic, New York, 1980).
  4. P. C. Lauterbur, “Image Formation by Induced Local Interactions. Examples Employing Nuclear Magnetic Resonance,” Nature London 242, 190 (1973). [CrossRef]
  5. W. P. Rothwell, D. R. Holecek, J. A. Kershaw, “NMR Imaging: Study of Fluid Absorption by Polymer Composites,” J. Polym. Sci. Polym. Lett. Ed. 22, 241 (1984). [CrossRef]
  6. W. P. Rothwell, P. P. Gentempo, “Nonmedical Applications of NMR Imaging,” Bruker Reports 1, 46 (1985).
  7. W. P. Rothwell, H. J. Vinegar, “Petrophysical Applications of NMR Imaging,” Appl. Opt. 24, this issue (1985). [CrossRef] [PubMed]
  8. P. Mansfield, P. C. Morris, “NMR Imaging in Biomedicine,” in Advances in Magnetic Resonance, Suppl. 2, J. S. Waugh, Ed. (Academic, New York, 1982).
  9. C. P. Slichter, Principles of Magnetic Resonance (Springer-Verlag, Berlin, 1978).
  10. U. Haeberlen, “High Resolution NMR in Solids: Selective Averaging,” in Advances in Magnetic Resonance, Suppl. 1, J. S. Waugh, Ed. (Academic, New York, 1976).
  11. P. A. Bottomly, “NMR Imaging Techniques and Applications: A Review,” Rev. Sci. Instrum. 53, 1319 (1982). [CrossRef]
  12. E. R. Andrew, “NMR Imaging,” Acc. Chem. Res. 16, 114 (1983). [CrossRef]
  13. K. Ohno, “Application of ESR Imaging to a Continuous Flow Method for Study of Kinetics of Short-Lived Radicals,” J. Magn. Reson. 49, 56 (1982); T. Herrling, N. Klimes, W. Karthe, U. Ewert, B. Ebert, “EPR Zeugmatography with Modulated Magnetic Filled Gradient,” J. Magn. Reson. 49, 203 (1982); K. Ohno, “ESR Imaging: A Deconvolution Method for Hyperfine Patterns,” J. Magn. Reson. 50, 145 (1982).
  14. I. L. Pykett, B.R. Rosen, “Nuclear Magnetic Resonance: In Vivo Proton Chemical Shift Imaging,” Radiology 149, 197 (1983). [PubMed]
  15. J. R. Singer, L. E. Crooks, “Nuclear Magnetic Resonance Blood Flow Measurements in the Human Brain,” Science London 221, 654 (1983).
  16. D. J. Bryant, J. A. Payne, D. N. Firmin, D. B. Longmore, “Measurement of Flow with NMR Imaging Using a Gradient Pulse and Phase Difference Technique,” J. Comput. Assist. Tomogr. 8, 588 (1984). [CrossRef] [PubMed]
  17. V. Waluch, W. G. Bradley, “NMR Even Echo Rephasing in Slow Laminar Flow,” J. Comput. Assist. Tomogr. 8, 594 (1984). [CrossRef] [PubMed]
  18. P. Brunner, R. R. Ernst, “Sensitivity and Performance Time in NMR Imaging,” J. Magn. Reson. 33, 83 (1979).
  19. W. S. Hinshaw, “Spin Mapping—Application of Moving Gradients to NMR,” Phys. Lett. A 48, 87 (1974); W. S. Hinshaw, “Image-Formation by Nuclear Magnetic-Resonance—Sensitive-Point Method,” J. Appl. Phys. 47, 3709 (1976). [CrossRef]
  20. R. Damadian, M. Goldsmith, L. Minkoff, “NMR in Cancer,” Physiol. Chem. Phys. 9, 97 (1977); R. Damadian, L. Minkoff, M. Goldsmith, J. A. Koutcher, “Field-Focusing Nuclear Magnetic Resonance (FONAR). Formation of Chemical Scans in Man,” Naturwissenschaften 65, 250 (1978). [CrossRef] [PubMed]
  21. W. S. Hinshaw, P. A. Bottomley, G. N. Holland, “Radiographic Thin-Section Image of Human Wrist by Nuclear Magnetic-Resonance,” Nature London 270, 722 (1977); W. S. Hinshaw, E. R. Andrew, P. A. Bottomley, G. N. Holland, W. S. Moore, B. S. Worthington, “Display of Cross Sectional Anatomy by Nuclear Magnetic Resonance Imaging,” and “In Vivo Study of the Forearm and Hand by Thin Section NMR Imaging,” Br. J. Radiol. 51, 273 (1978); Br. J. Radiol. 52, 36 (1979); E. R. Andrew, P. A. Bottomley, W. S. Hinshaw, G. N. Holland, W. S. Moore, C. Simaroj, “NMR Images by Multiple Sensitive Point Method—Application to Larger Biological Systems,” Phys. Med. Biol. 22, 971 (1977). [CrossRef] [PubMed]
  22. A. N. Garroway, P. K. Grannell, P. Mansfield, “Image Formation in NMR by a Selective Irradiative Process,” J. Phys. C 7, L457 (1974). [CrossRef]
  23. P. Mansfield, A. A. Maudsley, T. Baines, “Fast Scan Proton Density Imaging by NMR,” J. Phys. E 9, 271 (1976); P. Mansfield, A. A. Maudsley, “Medical Imaging by NMR,” J. Br. Radiol. 50, 188 (1977). [CrossRef]
  24. A. A. Maudsley, “Multiple-Line-Scanning Spin Density Imaging,” J. Magn. Reson. 41, 112 (1980).
  25. P. Mansfield, “Multi-Planar Image Formation using NMR Spin Echoes,” J. Phys. C 10, L55 (1977); P. Mansfield, I. L. Pykett, “Biological and Medical Imaging by NMR,” J. Magn. Reson. 29, 355 (1978). [CrossRef]
  26. P. Mansfield, A. A. Maudsley, “Planar Spin Imaging by NMR,” J. Phys. C 9, L409 (1976). [CrossRef]
  27. P. Mansfield, A. A. Maudsley, “Planar Spin Imaging by NMR,” J. Magn. Reson. 27, 101 (1977).
  28. A. Kumar, I. Welti, R. R. Ernst, “Imaging of Macroscopic Objects by NMR Fourier Zeugmatography,” Naturwissenshaftn 62, 34 (1975); A. Kumar, D. Welti, R. R. Ernst, “NMR Fourier Zeugmatography,” J. Magn. Reson. 18, 69 (1975). [CrossRef]
  29. W. A. Edelstein, J. M. S. Hutchison, G. Johnson, T. Red-path, “Spin Warp NMR Imaging and Applications to Human Whole-Body Imaging,” Phys Med. Biol. 25, 751 (1980). [CrossRef] [PubMed]
  30. D. I. Hoult, “Rotating Frame Zeugmatography,” J. Magn. Reson. 33, 183 (1979).
  31. P. C. Lauterbur, C.-M. Lai, “Zeugmatography by Reconstruction from Projections,” IEEE Trans. 27, 1227 (1980); C.-M. Lai, P. C. Lauterbur, “A Gradient Control Device for Complete Three-Dimensional Nuclear Magnetic Resonance Zeugmatographic Imaging,” J. Phys. E 13, 747 (1980); C.-M. Lai, “True Three-Dimensional Nuclear Magnetic Resonance Imaging by Fourier Reconstruction Zeugmatography,” J. Appl. Phys. 52, 1141 (1981). [CrossRef]
  32. A. A. Maudsley, S. K. Hilal, W. H. Perman, H. E. Simon, “Spatially Resolved High Resolution Spectroscopy by Four- Dimensional NMR,” J. Magn. Reson. 51, 147 (1983).
  33. A. Bax, A. F. Mehlkopf, J. Smidt, “Absorption Spectra From Phase-Modulated Spin Echoes,” J. Magn. Reson. 35, 373 (1979).
  34. L. E. Crooks, “Recent Developments in Nuclear Magnetic-Resonance Imaging and Flow Measurements,” IEEE Trans. Nucl. Sci. NS-31, 1006 (1984). [CrossRef]
  35. R. J. Sutherland, J. M. S. Hutchison, “Three-Dimensional NMR Imaging Using Selective Excitation,” J. Phys. E 11, 79 (1978). [CrossRef]
  36. L. E. Crooks, J. C. Hoenninger, M. Arakawa, “Method and Apparatus for Rapid NMR Imaging of Nuclear Densities Within an Object,” U.S. Patent4,318,043 (1982), “Method and Apparatus for Mapping Lines of Nuclear Density Within an Object using Nuclear Magnetic Resonance,” U.S. Patent4,297,637 (1981).
  37. R. J. Ordidge, private communication.
  38. P. Mansfield, P. K. Grannell, “NMR Diffraction in Solids,” J. Phys. C. 6, L422 (1973); P. Mansfield, P. K. Grannell, “Diffraction and Microscopy in Solids and Liquids by NMR,” Phys. Rev. 12, 3618 (1975). [CrossRef]
  39. R. A. Wind, C. S. Yannoni, “Selective Spin Imaging in Solids,” J. Magn. Reson. 36, 269 (1979).
  40. B. H. Suits, D. White, “NMR Imaging in Solids,” Solid State Commun. 50, 291 (1984). [CrossRef]
  41. A. N. Garroway, J. Baum, M. G. Munowitz, A. Pines, “NMR Imaging in Solids by Multiple-Quantum Resonance,” J. Magn. Reson. 60, 337 (1984).
  42. S. Emid, J. H. N. Creyghton, “High-Resolution NMR Imaging in Solids,” Physica B&C, 128, 81 (1985).
  43. I. R. Young et al., “Initial Clinical Evaluation of a Whole-Body Nuclear Magnetic-Resonance (NMR) Tomograph,” J. Comput. Assist. Tomogr. 6, 1 (1982). [CrossRef] [PubMed]
  44. W. A. Edelstein, P. A. Bottomley, H. R. Hart, L. S. Smith, “Signal, Noise, and Contrast in Nuclear Magnetic Resonance (NMR) Imaging,” J. Comput. Assist. Tomogr. 7, 391 (1983). [CrossRef] [PubMed]
  45. Abstracts, Third Annual Meeting of the Society of Magnetic Resonance in Medicine, 13–17 Aug., 1984, New York.
  46. E. Feig, F. Greenleaf, “Narrow-Band Chemical-Shift Imaging,” Appl. Opt. 24, 3977 (1985). [CrossRef] [PubMed]
  47. E. O. Stejskal, J. E. Tanner, “Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient,” J. Chem. Phys. 42, 288 (1965). [CrossRef]

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