OSA's Digital Library

Applied Optics

Applied Optics


  • Vol. 27, Iss. 9 — May. 1, 1988
  • pp: 1844–1849

Measurement depth of laser-induced tissue fluorescence with application to laser angioplasty

Arthur F. Gmitro, Francis W. Cutruzzola, Mark L. Stetz, and Lawrence I. Deckelbaum  »View Author Affiliations

Applied Optics, Vol. 27, Issue 9, pp. 1844-1849 (1988)

View Full Text Article

Enhanced HTML    Acrobat PDF (786 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Laser-induced fluorescence spectroscopy can be used to discriminate between normal and atherosclerotic tissue and guide the delivery of high-power laser energy for laser angioplasty. The depth of tissue from which fluorescence is measured should closely match the depth of laser ablation and, from a practical standpoint, should be neither too small nor too large. This paper investigates the depth of the fluorescence signal. A simple mathematical model is presented. An experimental procedure for determining this depth is described. The results agree well with the model. The implications of the findings to the development of a practical fluorescence-guided laser angioplasty system are discussed.

© 1988 Optical Society of America

Original Manuscript: October 19, 1987
Published: May 1, 1988

Arthur F. Gmitro, Francis W. Cutruzzola, Mark L. Stetz, and Lawrence I. Deckelbaum, "Measurement depth of laser-induced tissue fluorescence with application to laser angioplasty," Appl. Opt. 27, 1844-1849 (1988)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. T. R. Sanborn, D. P. Faxon, C. G. Haudenschild, S. B. Gottsman, T. J. Ryan, “Angiographic and Histopathologic Consequences of in-vivo Laser Radiation of Atherosclerotic Lesions,” Circulation Suppl. III 68, 145 (1983).
  2. G. Lee, R. M. Ikeda, R. M. Dwyer, H. Hussein, P. Dietrich, D. T. Mason, “Feasibility of Intravascular Laser Irradiation for in-vivo Visualization and Therapy of Cardiocirculatory Diseases,” Am. Heart J. 103, 1076 (1982). [CrossRef] [PubMed]
  3. J. M. Isner et al., “Factors Contributing to Perforations Resulting from Laser Coronary Angioplasty: Observations in an Intact Human Postmortum Preparation of Interoperative Laser Angioplasty,” Circulation Suppl. II 72, 191 (1985).
  4. R. R. Alfano, D. Tata, J. Corder, P. Tomashefsky, F. Longo, M. A. Alfano, “Laser Induced Fluorescence Spectroscopy from Native Cancerous and Normal Tissues,” IEEE J. Quantum Electron. QE-20, 1507 (1984). [CrossRef]
  5. R. R. Alfano et al., “Human Teeth With and Without Caries Studied by Laser Scattering Fluorescence and Absorption Spectroscopy,” IEEE J. Quantum Electron. QE-20, 1512 (1984). [CrossRef]
  6. D. H. Blackenhorn, H. Braunstein, “Carotenoids in Man. III. The Microscopic Pattern of Fluorescence in Atheromas, and Its Relation to Their Growth,” J. Clin. Invest. 37, 160 (1958). [CrossRef]
  7. M. R. Prince, R. Gargolis, T. Deutsch, J. A. Parrish, A. R. Oseroff, “Selective Light Absorption in Atheromas,” Clin. Res. 33, 218A (1985).
  8. I. Banga, M. Bihari-Varga, “Investigations of Free and Elastin-Bound Fluorescent Substances Present in the Atherosclerotic Lipid and Calcium Plaques,” Connect. Tissue Res. 2, 237 (1974). [CrossRef] [PubMed]
  9. M. Sartori, P. D. Henry, R. Roberts, R. P. Chin, M. J. Berry, “Estimation of Arterial Wall Thickness and Detection of Atherosclerosis by Laser Induced Argon Fluorescence,” J. Am. Coll. Cardiol. 7, 207A (1986).
  10. C. Kittrell et al., “Diagnosis of Fibrous Arterial Atherosclerosis Using Fluorescence,” Appl. Opt. 24, 2280 (1985). [CrossRef] [PubMed]
  11. L. I. Deckelbaum, J. K. Lam, H. S. Cabin, K. S. Clubb, M. B. Long, “Discrimination of Normal and Aterosclerotic Aorta by Laser-Induced Fluorescence,” Lasers in Medicine and Surgery 7, 330 (1987). [CrossRef]
  12. L. Esterowitz, C. A. Hoffman, D. C. Tran, “Angioplasty with a Laser and Fiber Optics at 2.94 μm,” Proc. Soc. Photo-Opt. Instrum. Eng. 605, 32 (1986).
  13. L. I. Deckelbaum et al., “Reduction of Laser-Induced Pathologic Tissue Injury Using Pulsed Energy Delivery,” Am. J. Cardiol. 56, 662 (1985). [CrossRef] [PubMed]
  14. L. I. Deckelbaum et al., “Fiberoptic Laser-Induced Fluorescence Detection of Atherosclerosis and Plaque Ablation: Potential for Laser Angioplasty Guidance,” Circulation Suppl. II 74, 7 (1986).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited