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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 27, Iss. 9 — May. 1, 1988
  • pp: 1844–1849

Measurement depth of laser-induced tissue fluorescence with application to laser angioplasty

Arthur F. Gmitro, Francis W. Cutruzzola, Mark L. Stetz, and Lawrence I. Deckelbaum  »View Author Affiliations


Applied Optics, Vol. 27, Issue 9, pp. 1844-1849 (1988)
http://dx.doi.org/10.1364/AO.27.001844


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Abstract

Laser-induced fluorescence spectroscopy can be used to discriminate between normal and atherosclerotic tissue and guide the delivery of high-power laser energy for laser angioplasty. The depth of tissue from which fluorescence is measured should closely match the depth of laser ablation and, from a practical standpoint, should be neither too small nor too large. This paper investigates the depth of the fluorescence signal. A simple mathematical model is presented. An experimental procedure for determining this depth is described. The results agree well with the model. The implications of the findings to the development of a practical fluorescence-guided laser angioplasty system are discussed.

© 1988 Optical Society of America

History
Original Manuscript: October 19, 1987
Published: May 1, 1988

Citation
Arthur F. Gmitro, Francis W. Cutruzzola, Mark L. Stetz, and Lawrence I. Deckelbaum, "Measurement depth of laser-induced tissue fluorescence with application to laser angioplasty," Appl. Opt. 27, 1844-1849 (1988)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-27-9-1844

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