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Applied Optics

Applied Optics


  • Vol. 28, Iss. 6 — Mar. 15, 1989
  • pp: 1115–1121

Rod increment thresholds in cone-rod dystrophy

David W. Yates, Deborah J. Derlacki, David R. Pepperberg, Kenneth R. Alexander, and Gerald A. Fishman  »View Author Affiliations

Applied Optics, Vol. 28, Issue 6, pp. 1115-1121 (1989)

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Rod system increment threshold functions (ITFs) were studied in patients with cone–rod dystrophy (CRD). Rod thresholds (It) for a 104-min, 500-nm test stimulus (TS), superimposed on an 11° long wavelength background (luminance Ib), were measured in eleven CRD patients and fourteen normal subjects. Thresholds in normals were also measured using a 7-min TS. A modified version of Weber’s law [ log I t = log K   +  log ( I b n   + c ) ] was fitted to the data from each subject and test condition to yield a description of the ITF in terms of the free parameters K, c, and n. Four of the CRD patients exhibited an abnormally high absolute threshold; of these, two showed abnormalities in K and c consistent with a reduced efficiency of quantum capture by the rods. Abnormalities in the ITFs of CRD patients did not resemble the effect of reducing the diameter of the TS from 104 to 7 min in normals. This suggests that threshold abnormalities in the CRD patients did not result from altered spatial summation. The results illustrate use of a parametric representation of the ITF to evaluate the loss of sensitivity in visual disorders.

© 1989 Optical Society of America

Original Manuscript: June 2, 1988
Published: March 15, 1989

David W. Yates, Deborah J. Derlacki, David R. Pepperberg, Kenneth R. Alexander, and Gerald A. Fishman, "Rod increment thresholds in cone-rod dystrophy," Appl. Opt. 28, 1115-1121 (1989)

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