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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 28, Iss. 6 — Mar. 15, 1989
  • pp: 1145–1150

Properties of the human cone system electroretinogram during light adaptation

Neal S. Peachey, Kenneth R. Alexander, Gerald A. Fishman, and Deborah J. Derlacki  »View Author Affiliations


Applied Optics, Vol. 28, Issue 6, pp. 1145-1150 (1989)
http://dx.doi.org/10.1364/AO.28.001145


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Abstract

Changes in the response characteristics of the flash electroretinogram (ERG) of the human cone system were studied during the time course of adaptation to a cone-isolating ganzfeld background. During light adaptation, the amplitudes of the b- and i-waves increased, while the implicit time of the b-wave decreased. The amplitude of the a-wave and the implicit times of the a- and i -waves did not change systematically during light adaptation. Luminance-response functions for b-wave amplitude were obtained at discrete times following background onset and were analyzed using the hyperbolic equation R/Rmax= Ln/(Ln+ Kn). The increase in b-wave amplitude was characterized by increases in Rmax, K, and n. The decrease in b-wave implicit time was of a similar magnitude at all flash luminances. The amplitude increase of the i-wave only occurred at moderate flash luminances. The results provide a basis for optimizing the clinical recording of cone-isolated single-flash ERGs.

© 1989 Optical Society of America

History
Original Manuscript: May 26, 1988
Published: March 15, 1989

Citation
Neal S. Peachey, Kenneth R. Alexander, Gerald A. Fishman, and Deborah J. Derlacki, "Properties of the human cone system electroretinogram during light adaptation," Appl. Opt. 28, 1145-1150 (1989)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-28-6-1145


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References

  1. H. M. Burian, “Electric Responses of the Human Visual System,” Arch. Ophthalmol. 51, 509 (1954). [CrossRef]
  2. J. C. Armington, W. R. Biersdorf, “Long-Term Light Adaptation of the Human Electroretinogram,” J. Comp. Physiol. Psychol. 51, 1 (1958). [CrossRef] [PubMed]
  3. W. R. Biersdorf, J. C. Armington, “Level of Light Adaptation and the Human Electroretinogram,” J. Opt. Soc. Am. 50, 78 (1960). [CrossRef] [PubMed]
  4. P. Gouras, C. J. Mackay, L. Ivert, R. N. Mittl, J. Neuwirth, H. Eggers, “Computer-Assisted Spectral Electroretinography in Vitrectomy Patients,” Ophthalmology 92, 83 (1985);C. J. MacKay, P. Gouras, “Light-Adaptation Augments the Amplitude of the Human Cone ERG,” Invest. Ophthalmol. Vis. Sci. Suppl. 26, 323 (1985). [PubMed]
  5. P. Lachapelle, “Analysis of the Photopic Electroretinogram Recorded Before and After Dark Adaptation,” Can. J. Ophthalmol. 22, 354 (1987). [PubMed]
  6. Y. Miyake, M. Horiguchi, I. Ota, A. Tokabayashi, “Adaptational Change in Cone-Mediated Electroretinogram in Human and Carp,” Neurosci. Res. Suppl. 8, S1 (1988).
  7. R. G. Weleber, A. Eisner, “Retinal Function and Physiological Studies,” in Retinal Dystrophies and Degeneration, D. A. Newsome, Ed. (Raven Press, New York, 1988), Chap. 3.
  8. A similar effect has been noted for the cone flicker ERG in the frog9 and man.10
  9. D. C. Hood, “Adaptational Changes in the Cone System of the Isolated Frog Retina,” Vision Res. 12, 875 (1972). [CrossRef] [PubMed]
  10. Y. Miyake, M. Horiguchi, I. Ota, N. Shiroyama, “Characteristic ERG Flicker Anomaly in Incomplete Congenital Stationary Night Blindness,” Invest. Ophthalmol. Vis. Sci. 28, 1816 (1987). [PubMed]
  11. N. S. Peachey, G. A. Fishman, D. J. Derlacki, K. R. Alexander, “Rod and Cone Dysfunction in Carriers of X-Linked Retinitis Pigmentosa,” Ophthalmology 95, 677 (1988). [PubMed]
  12. M. Nagata, “Studies on the Photopic ERG of the Human Retina,” Jpn. J. Ophthalmol. 7, 96 (1963).
  13. N. S. Peachey, K. R. Alexander, G. A. Fishman, “The Luminance-Response Function of the Dark-Adapted Human Electroretinogram,” Vision Res. (to be published).
  14. The time constant of the exponential fitted to K was 2.85 min, slightly longer than that for log K.
  15. A similar luminance-response function has been reported for the ground squirrel d-wave by K. Tansley, R. M. Copenhaver, R.D. Gunkel, “Some Observations on the Off-Effect of the Mammalian Cone Electroretinogram,” J. Opt. Soc. Am. 51, 207 (1961). [CrossRef] [PubMed]
  16. R. H. Steinberg, R. A. Linsenmeier, E. R. Griff, “Retinal Pigment Epithelial Cell Contributions to the Electroretinogram and Electrooculogram,” Prog. Retinal Res. 4, 33 (1985). [CrossRef]
  17. N. S. Peachey, G. A. Fishman, unpublished observations on four patients.
  18. R. A. Normann, I. Perlman, “The Effects of Background Illumination on the Photoresponses of Red and Green Cones,” J. Physiol. 286, 491 (1979). [PubMed]
  19. R. A. Normann, F. S. Werblin, “Control of Retinal Sensitivity. I. Light and Dark Adaptation of Vertebrate Rods and Cones,” J. Gen. Physiol. 63, 37 (1974). [CrossRef] [PubMed]
  20. H. R. Matthews, R. L. W. Murphy, G. L. Fain, T. D. Lamb, “Photoreceptor Light Adaptation is Mediated by Cytoplasmic Calcium Concentration,” Nature London 334, 67 (1988). [CrossRef] [PubMed]
  21. K. Nakatani, K.-W. Yau, “Calcium and Light Adaptation in Retinal Rods and Cones,” Nature London 334, 69 (1988). [CrossRef] [PubMed]
  22. R. D. Penn, W. A. Hagins, “Signal Transmission Along Retinal Rods and the Origin of the Electroretinographic a-Wave,” Nature London 223, 201 (1969). [CrossRef] [PubMed]

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