OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 28, Iss. 6 — Mar. 15, 1989
  • pp: 1158–1164

S cone pathway sensitivity in eyes with high risk and low risk drusen characteristics

Janet S. Sunness, Robert W. Massof, Neil M. Bressler, and Susan B. Bressler  »View Author Affiliations


Applied Optics, Vol. 28, Issue 6, pp. 1158-1164 (1989)
http://dx.doi.org/10.1364/AO.28.001158


View Full Text Article

Enhanced HTML    Acrobat PDF (823 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A method of measuring S cone pathway sensitivity which corrects internally for media absorption, flicker sensitivity variations, and diffuse losses in retinal sensitivity is presented. Foveal S cone pathway sensitivity was measured in elderly subjects who had no ophthalmoscopically detectable retinal abnormality other than the presence of drusen. S cone pathway sensitivity was decreased in the elderly group compared with a group of young normals. The elderly group was subdivided by drusen characteristics present in fundus photographs into a group felt to be at high risk of developing age-related macular degeneration and a group judged to be at low risk. There was a mean difference in age of 7 yr between the groups. There was a weak association between a lower S cone pathway sensitivity and the presence of high risk drusen characteristics not attributable to the age difference. Yellow flicker sensitivity better separated the high risk group from the low risk group, but this was attributable to the mean difference in age between the groups. The limited usefulness of the drusen risk classification in assessing the likelihood of developing severe age-related macular degeneration highlights the need for following a group of drusen patients prospectively to assess the true worth of S cone pathway sensitivity in this disease.

© 1989 Optical Society of America

History
Original Manuscript: August 4, 1988
Published: March 15, 1989

Citation
Janet S. Sunness, Robert W. Massof, Neil M. Bressler, and Susan B. Bressler, "S cone pathway sensitivity in eyes with high risk and low risk drusen characteristics," Appl. Opt. 28, 1158-1164 (1989)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-28-6-1158


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. H. M. Leibowitz, D. E. Krueger, L. R. Maunder et al., “The Framingham Eye Study Monograph,” Surv. Ophthalmol. 24 (Suppl), 335 (1980). [PubMed]
  2. Macular Photocoagulation Study Group, “Argon Laser Photocoagulation for Senile Macular Degeneration: Results of a Randomized Clinical Trial,” Arch. Ophthalmol. 100, 912 (1982). [PubMed]
  3. D. A. Newsome, M. Swartz, N. C. Leone et al., “Oral Zinc in Macular Degeneration,” Arch. Ophthalmol. 106, 192 (1988). [CrossRef] [PubMed]
  4. F. L. Ferris, “Senile Macular Degeneration: Review of Epidemiologic Features,” Am. J. Epidemiol. 118, 132 (1983). [PubMed]
  5. Z. Gregor, A. C. Bird, I. H. Chisholm, “Senile Disciform Macular Degeneration in the Second Eye,” Br. J. Ophthalmol. 61, 141 (1977). [CrossRef] [PubMed]
  6. E. S. Gragoudas, S. R. Chandra, E. Friedman et al., “Disciform Degeneration of the Macula: II. Pathogenesis,” Arch. Ophthalmol. 94, 755 (1976). [CrossRef] [PubMed]
  7. E. R. Strahlman, S. L. Fine, A. Hillis, “The Second Eye of Patients with Senile Macular Degeneration,” Arch. Ophthalmol. 101, 1191 (1983). [CrossRef] [PubMed]
  8. W. E. Smiddy, S. L. Fine, “Prognosis of Patients with Bilateral Macular Drusen,” Ophthalmology 91, 271 (1984). [PubMed]
  9. W. R. Green, P. H. McDonnell, J. H. Yeo, “Pathologic Features of Senile Macular Degeneration,” Ophthalmology 92, 615 (1985). [PubMed]
  10. S. H. Sarks, “Drusen and their Relationship to Senile Macular Degeneration,” Aust. J. Ophthalmol. 8, 117 (1980). [CrossRef] [PubMed]
  11. N. M. Bressler, S. B. Bressler, J. M. Seddon, E. S. Gragoudas, L. Jacobson, “Drusen Characteristics in Patients with Exudative versus Nonexudative Age-related Macular Degeneration,” Retina 8, 109 (1988). [CrossRef] [PubMed]
  12. F. L. Ferris, S. L. Fine, L. A. Hyman, “Age-Related Macular Degeneration and Blindness due to Neovascular Maculopathy,” Arch. Ophthalmol. 102, 1640 (1984). [CrossRef] [PubMed]
  13. J. Pokorny, V. C. Smith, G. Verriest, A. J. L. G. Pinckers, Congenital and Acquired Color Vision Defects (Grune & Stratton, New York, 1979).
  14. S. L. Alvarez, P. E. King-Smith, S. K. Bhargava, “Spectral Thresholds in Macular Degeneration,” Br. J. Ophthalmol. 67, 508 (1983). [CrossRef] [PubMed]
  15. G. Haegerstrom-Portnoy, B. Brown, “Two-Color Increment Thresholds in Early Age-Related Maculopathy,” Clin. Vis. Sci (in press).
  16. R. A. Applegate, A. J. Adams, J. C. Cavender, F. Zisman, “Early Color Vision Changes in Age-Related Maculopathy,” Appl. Opt. 26, 1458 (1987). [CrossRef] [PubMed]
  17. A. Eisner, S. A. Fleming, M. L. Klein, W. M. Mauldin, “Sensitivities in Older Eyes with Good Acuity: Eyes whose Fellow Eye had Exudative AMD,” Invest. Ophthalmol. Vis. Sci. 28, 1832 (1987). [PubMed]
  18. A. J. Adams, F. Zisman, R. Rodic, J. C. Cavender, “Chromaticity and Luminosity Changes in Glaucoma and Diabetes,” Doc. Ophthalmol. Proc. Ser. 33, 413 (1982).
  19. A. Eisner, S. A. Fleming, M. L. Klein, W. M. Mauldin, “Sensitivities in Older Eyes with Good Acuity: Cross-Sectional Norms,” Invest. Ophthalmol. Vis. Sci. 28, 1824 (1987). [PubMed]
  20. M. E. Schneck, A. J. Adams, “Changes in S-Cone System Sensitivity and Ocular Media Absorption,” Invest. Ophthalmol. Vis. Sci. 29 (Suppl.), 301 (1988).
  21. E. Simonson, N. Enzer, S. S. Blankstein, “The Influence of Age on the Fusion Frequency of Flicker,” J. Exp. Psychol. 29, 252 (1941). [CrossRef]
  22. P. E. King-Smith, D. Carden, “Luminance and Opponent-Color Contributions to Visual Detection and Adaptation and toTemporal and Spatial Integration,” J. Opt. Soc. Am. 66, 709 (1976). [CrossRef] [PubMed]
  23. C. R. Ingling, B. H.-P. Tsou, “Orthogonal Combinations of the Three Visual Channels,” Vis. Res. 17, 1075 (1977). [CrossRef] [PubMed]
  24. G. Wyszecki, W. S. Stiles, Color Science (Wiley, New York, 1982).
  25. W. S. Stiles, “Color Vision: The Approach through Increment-Threshold Sensitivity,” Proc. Natl. Acad. Sci. 45, 229 (1959). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited