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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 30, Iss. 31 — Nov. 1, 1991
  • pp: 4515–4520

Monte Carlo simulation of light transmission through living tissues

Yasuo Hasegawa, Yukio Yamada, Mamoru Tamura, and Yasutomo Nomura  »View Author Affiliations


Applied Optics, Vol. 30, Issue 31, pp. 4515-4520 (1991)
http://dx.doi.org/10.1364/AO.30.004515


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Abstract

To analyze the fundamental characteristics of light transmitted through living tissues, we used the Monte Carlo method to trace the paths of the rays incident upon slabs of particles. The slabs contained either (i) two types of scattering particles in a solution or (ii) one type of particle with pigment added to the solution. Temporal analyses of the transmittance have illustrated that the differences in the optical density among the slabs having different absorption coefficients with the same scattering coefficient vary linearly with time. Also, their gradients have been shown to be proportional to the differences in the absorption coefficients, thus verifying the microscopic Beer–Lambert law in highly scattering media when temporally resolved measurement is used.

© 1991 Optical Society of America

History
Original Manuscript: October 23, 1989
Published: November 1, 1991

Citation
Yasuo Hasegawa, Yukio Yamada, Mamoru Tamura, and Yasutomo Nomura, "Monte Carlo simulation of light transmission through living tissues," Appl. Opt. 30, 4515-4520 (1991)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-30-31-4515


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References

  1. F. F. Jöbsis, “Nonivasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters,” Science, 198, 1264–1267 (1977). [CrossRef] [PubMed]
  2. P. van der Zee, D. T. Delpy, “Simulation of the point spread function for light in tissue by a Monte Carlo method,” in Oxygen Transport to TissueI. A. Silver, A. Silver, eds. (Plenum, New York, 1987), Vol. IX.
  3. P. van der Zee, D. T. Delpy, “Computed point spread functions for light in tissue using a measured volume scattering function,” Adv. Exp. Med. Biol. 222, 191–197 (1988). [PubMed]
  4. D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, J. Wyatt, “Estimation of optical pathlength through tissue from direct flight measurement,” Phys. Med. Biol. 33, 1433–1442 (1988). [CrossRef] [PubMed]
  5. B. C. Wilson, G. Adam, “A Monte Carlo model for the absorption and flux distributions of light in tissue,” Med. Phys. 10, 824–830 (1983). [CrossRef] [PubMed]
  6. S. T. Flock, B. C. Wilson, M. S. Patterson, “Total attenuation coefficients and scattering phase functions of tissues and phantom materials,” Med. Phys. 14, pp. 835–843 (1987). [CrossRef] [PubMed]
  7. B. C. Wilson, M. S. Patterson, S. T. Flock, J. D. Moulton, “The optical absorption and scattering properties of tissues in the visible and near-infrared wavelength range,” in Light in Biology and Medicine, R. H. Douglas, J. Moan, F. Dall'Acqua, eds. (Plenum, New York, 1988), Vol. 1, pp. 45–52. [CrossRef]
  8. S. L. Jacques, “Time resolved propagation of ultrashort laser pulses within turbid tissues,” Appl. Opt. 28, 2223–2229 (1989). [CrossRef] [PubMed]
  9. J. M. Maarek, G. Jarry, J. Crowe, M.-H. Bui, D. Laurent, “Simulation of laser tomoscopy in a heterogeneous biological medium,” Med. Biol. Eng. Comput. 24, 407–414 (1986). [CrossRef] [PubMed]
  10. A. Ishimaru, Wave Propagation and Scattering in Random Media (Academic, New York, 1978), Vol. 1, Chap. 9.
  11. S. Ito, K. Furutsu, “Theory of light pulse propagation through thick clouds,” J. Opt. Soc. Am. 70, 366–374 (1980). [CrossRef]
  12. M. S. Patterson, B. Chance, B. C. Wilson, “Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties,” Appl. Opt., 28, 2331–2336 (1989). [CrossRef] [PubMed]
  13. B. Chance, J. S. Leigh, H. Miyake, D. S. Smith, S. Nioka, R. Greenfeld, M. Finander, K. Kaufmann, W. Levy, M. Young, P. Cohen, H. Yoshioka, R. Boretsky, “Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain,” Proc. Natl. Acad. Sci. USA 85, 4971–4975 (1988). [CrossRef] [PubMed]
  14. O. Hazeki, M. Tamura, “Quantitative analysis of hemoglobin oxygenation state of rat brain in situ by near-infrared spectrophotometry,” J. Appl. Physiol. 64, 796–802 (1988). [PubMed]
  15. A. Seiyama, O. Hazeki, M. Tamura, “Noninvasive quantitative analysis of blood oxygenation in rat skeletal muscle,” J. Biochem. 103, 419–424 (1988). [PubMed]
  16. Y. Nomura, O. Hazeki, T. Ariga, M. Tamura, “Exponential attenuation of light along nonlinear path through the biological model,” Adv. Exp. Med. Biol. 248, 77–80 (1989). [CrossRef] [PubMed]
  17. R. S. Chadwick, I.-D. Chang, “A laser study of the motion of particles suspended in a slow viscous shear flow,” J. Colloid Interface Sci. 4, 516–534 (1973). [CrossRef]
  18. J. J. Duderstadt, L. J. Hamilton, Nuclear Reactor Analysis (Wiley, New York, 1976), pp. 140–144.

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