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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 33, Iss. 28 — Oct. 1, 1994
  • pp: 6699–6710

Time-gated transillumination of biological tissues and tissuelike phantoms

Gerhard Mitic, Jochen Kölzer, Johann Otto, Erich Plies, Gerald Sölkner, and Wolfgang Zinth  »View Author Affiliations


Applied Optics, Vol. 33, Issue 28, pp. 6699-6710 (1994)
http://dx.doi.org/10.1364/AO.33.006699


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Abstract

The applicability and limits of time-resolved transillumination to determine the internal details of biological tissues are investigated by phantom experiments. By means of line scans across a sharp edge, the spatial resolution (Δx) and its dependence on the time-gate width (Δt) can be determined. Additionally, measurements of completely absorbing bead pairs embedded in a turbid medium demonstrate the physical resolution in a more realistic case. The benefit of time resolution is especially high for a turbid medium with a comparatively small reduced scattering coefficient of approximately μs′ = 0.12 mm−1. Investigations with partially absorbing beads and filled plastic tubes demonstrate the high sensitivity of time-resolving techniques with respect to spatial variations in scattering or absorption coefficients that are due to the embedded disturber. In particular, it is shown that time gating is sensitive to variations in scattering coefficients.

© 1994 Optical Society of America

History
Original Manuscript: October 5, 1993
Revised Manuscript: February 18, 1994
Published: October 1, 1994

Citation
Gerhard Mitic, Jochen Kölzer, Johann Otto, Erich Plies, Gerald Sölkner, and Wolfgang Zinth, "Time-gated transillumination of biological tissues and tissuelike phantoms," Appl. Opt. 33, 6699-6710 (1994)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-33-28-6699


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