Accurate concentration measurements of glucose, lactic acid, and creatinine in saline solution have been achieved with near-IR Raman spectroscopy and a partial least-squares analysis. The Raman spectra were acquired remotely through optical fibers. A root-mean-squared prediction error of 1.2 mM for glucose concentration was achieved in 100 s. Concentrations of other analytes were predicted with similar accuracy.
© 1996 Optical Society of America
Original Manuscript: June 7, 1995
Revised Manuscript: September 5, 1995
Published: January 1, 1996
Andrew J. Berger, Yang Wang, and Michael S. Feld, "Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy," Appl. Opt. 35, 209-212 (1996)