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Applied Optics

Applied Optics


  • Vol. 35, Iss. 1 — Jan. 1, 1996
  • pp: 209–212

Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy

Andrew J. Berger, Yang Wang, and Michael S. Feld  »View Author Affiliations

Applied Optics, Vol. 35, Issue 1, pp. 209-212 (1996)

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Accurate concentration measurements of glucose, lactic acid, and creatinine in saline solution have been achieved with near-IR Raman spectroscopy and a partial least-squares analysis. The Raman spectra were acquired remotely through optical fibers. A root-mean-squared prediction error of 1.2 mM for glucose concentration was achieved in 100 s. Concentrations of other analytes were predicted with similar accuracy.

© 1996 Optical Society of America

Original Manuscript: June 7, 1995
Revised Manuscript: September 5, 1995
Published: January 1, 1996

Andrew J. Berger, Yang Wang, and Michael S. Feld, "Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy," Appl. Opt. 35, 209-212 (1996)

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