OSA's Digital Library

Applied Optics

Applied Optics


  • Vol. 35, Iss. 19 — Jul. 1, 1996
  • pp: 3432–3440

Time-gated viewing studies on tissuelike phantoms

R. Berg, S. Andersson-Engels, O. Jarlman, and S. Svanberg  »View Author Affiliations

Applied Optics, Vol. 35, Issue 19, pp. 3432-3440 (1996)

View Full Text Article

Enhanced HTML    Acrobat PDF (367 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A time-gated technique to enhance viewing through highly scattering media such as tissue is discussed. Experiments have been performed on tissuelike plastic phantoms to determine the possibilities and limitations of the technique. The effects of the time-gate width and the localization, size, and optical properties of hidden objects have been studied. A computer model to simulate light propagation in tissue is also presented. The predictions of the model are compared with experimental results.

© 1996 Optical Society of America

Original Manuscript: July 20, 1995
Revised Manuscript: January 2, 1996
Published: July 1, 1996

R. Berg, S. Andersson-Engels, O. Jarlman, and S. Svanberg, "Time-gated viewing studies on tissuelike phantoms," Appl. Opt. 35, 3432-3440 (1996)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. G. J. Müller, B. Chance, R. R. Alfano, S. R. Arridge, J. Beuthan, E. Gratton, M. Kaschke, B. R. Masters, S. Svanberg, P. van der Zee, eds., Medical Optical Tomography: Functional Imaging and Monitoring, SPIE Institute Series Vol. SI11 (Society of Photo-Optical and Instrumentation Engineers, Bellingham, Wash., 1993).
  2. R. J. Bartrum, H. C. Crow, “Transillumination lightscanning to diagnose breast cancer: a feasibility study,” Am. J. Radiol. 142, 409–414 (1984).
  3. M. Swift, D. Morrell, R. B. Massey, C. L. Chase, “Incidence of cancer in 161 families affected by ataxia-telangiectasia,” N. Engl. J. Med. 325, 1831–1836 (1991). [CrossRef] [PubMed]
  4. B. C. Wilson, M. S. Patterson, S. T. Flock, D. R. Wyman, “Tissue optical properties in relation to light propagation models and in vivo dosimetry,” in Photon Migration in Tissue, B. Chance, ed. (Plenum, New York, 1989), pp. 24–42.
  5. S. Andersson-Engels, R. Berg, S. Svanberg, O. Jarlman, “Time-resolved transillumination for medical diagnostics,” Opt. Lett. 15, 1179–1181 (1990). [CrossRef] [PubMed]
  6. B. Chance, A. Katzir, eds., Time-Resolved Spectroscopy and Imaging of Tissue, SPIE1431, 1–332 (1991).
  7. K. G. Spears, J. Serafin, N. H. Abramson, X. Zhu, H. Bjelkhagen, “Chrono-coherent imaging for medicine,” IEEE Trans. Biomed. Eng. 36, 1210–1221 (1989). [CrossRef] [PubMed]
  8. H. Chen, Y. Chen, D. Dilworth, E. Leith, J. Lopez, J. Valdmanis, “Two-dimensional imaging through diffusing media using 150-fs gated electronic holography techniques,” Opt. Lett. 16, 487–489 (1991). [CrossRef] [PubMed]
  9. M. Toida, T. Ichimura, H. Inaba, “The first demonstration of laser computed tomography achieved by coherent detection imaging method for biomedical applications,” Inst. Electron. Inf. Commun. Jpn. Trans. E74, 1692–1694 (1991).
  10. K. M. Yoo, Q. Xing, R. R. Alfano, “Imaging objects hidden in highly scattering media using femtosecond second-harmonic-generation cross-correlation time gating,” Opt. Lett. 16, 1019–1021 (1991). [CrossRef] [PubMed]
  11. L. M. Wang, P. P. Ho, R. R. Alfano, “Double-stage picosecond Kerr gate for ballistic time-gated optical imaging in turbid media,” Appl. Opt. 32, 535–540 (1993). [CrossRef] [PubMed]
  12. M. D. Duncan, R. Mahon, L. L. Tankersley, R. Reintjes, “Time-gated imaging through scattering media using stimulated Raman amplification,” Opt. Lett. 16, 1868–1870 (1991). [CrossRef] [PubMed]
  13. G. W. Faris, M. Banks, “Upconverting time gate for imaging through highly scattering media,” Opt. Lett. 19, 1813–1815 (1994). [CrossRef] [PubMed]
  14. J. C. Hebden, K. S. Wong, “Time-resolved optical tomography,” Appl. Opt. 32, 372–380 (1993). [CrossRef] [PubMed]
  15. S. Andersson-Engels, R. Berg, A. Persson, S. Svanberg, “Multispectral tissue characterization with time-resolved detection of diffusely scattered white light,” Opt. Lett. 18, 1697–1699 (1993). [CrossRef] [PubMed]
  16. R. Berg, O. Jarlman, S. Svanberg, “Medical transillumination using short-pulse diode lasers,” Appl. Opt. 32, 574–579 (1993). [CrossRef] [PubMed]
  17. J. Fishkin, E. Gratton, M. J. vandeVen, W. W. Mantulin, “Diffusion of intensity modulated near-infrared light in turbid media,” in Time-Resolved Spectroscopy and Imaging of Tissue, B. Chance, A. Katzir, eds., SPIE1431, 122–135 (1991). [CrossRef]
  18. A. Knüttel, J. M. Schmitt, J. R. Knutson, “Spatial localization of absorbing bodies by interfering diffusive photon-density waves,” Appl. Opt. 32, 381–389 (1993). [CrossRef] [PubMed]
  19. S. J. Madsen, E. R. Anderson, R. C. Haskell, B. J. Tromberg, “Portable, high-bandwidth frequency-domain photon migration instrument for tissue spectroscopy,” Opt. Lett. 19, 1934–1936 (1994). [CrossRef] [PubMed]
  20. B. Chance, J. S. Leigh, H. Miyake, D. S. Smith, S. Nioka, R. Greenfeld, M. Finander, K. Kaufmann, W. Levy, M. Young, P. Cohen, H. Yoshioka, R. Boretsky, “Comparison of time-resolved and -unresolved measurement of deoxyhemoglobin in brain,” Proc. Natl. Acad. Sci. USA 85, 4971–4975 (1988). [CrossRef] [PubMed]
  21. D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, J. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol. 33, 1433–1442 (1988). [CrossRef] [PubMed]
  22. R. Berg, S. Andersson-Engels, O. Jarlman, S. Svanberg, “Time-resolved transillumination for medical diagnostics,” in Time-Resolved Spectroscopy and Imaging of Tissue, B. Chance, A. Katzir, eds., SPIE1431, 110–119 (1991). [CrossRef]
  23. S. Andersson-Engels, R. Berg, S. Svanberg, “Effects of optical constants on time-gated transillumination of tissue and tissue-like media,” J. Photochem. Photobiol. 16, 155–167 (1992). [CrossRef]
  24. M. S. Patterson, B. Chance, B. C. Wilson, “Time resolved reflectance and transmittance for the noninvasive measurement of optical properties,” Appl. Opt. 28, 2331–2336 (1989). [CrossRef] [PubMed]
  25. S. L. Jacques, “Time resolved propagation of ultrashort laser pulses within turbid tissue,” Appl. Opt. 28, 2223–2229 (1989). [CrossRef] [PubMed]
  26. M. S. Patterson, S. J. Madsen, J. D. Moulton, B. C. Wilson, “Diffusion equation representation of photon migration in tissue,” MTT-S Digest905–908 (1991).
  27. M. S. Patterson, J. D. Moulton, B. C. Wilson, K. W. Berndt, J. R. Lakowicz, “Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue,” Appl. Opt. 30, 4474–4476 (1991). [CrossRef] [PubMed]
  28. W. H. Press, B. P. Flannery, S. A. Teukolsky, W. T. Vetterling, Numerical Recipes in Pascal (Cambridge U. Press, Cambridge, 1990).
  29. C. Lindquist, “Numerical diffusion modelling of light propagation in turbid media for medical diagnostics,” Lund Rep. At. Phys.LRAP-157, 1–47 (1994).
  30. J. W. Pickering, S. A. Prahl, N. van Wieringen, J. F. Beek, H. J. C. M. Sterenborg, M. J. C. van Gemert, “Double-integrating-sphere system for measuring the optical properties of tissue,” Appl. Opt. 32, 399–410 (1993). [CrossRef] [PubMed]
  31. M. J. Homer, “Breast imaging: pitfalls, controversies and some practical thoughts,” Radiol. Clin. North Am. 23, 459–472 (1985). [PubMed]
  32. G. Mitic, J. Kölzer, J. Otto, E. Plies, G. Sölkner, W. Zinth, “Time-gated transillumination of biological tissues and tissue-like phantoms,” Appl. Opt. 33, 6699–6710 (1994). [CrossRef] [PubMed]
  33. J. J. Dolne, K. M. Yoo, F. Liu, R. R. Alfano, “Spatial frequency imaging through random scattering media,” in Advances in Optical Imaging and Photon Migration, R. R. Alfano, ed., Vol. 21 of OSA Proceedings Series (Optical Society of America, Washington, D. C., 1994), pp. 284–287.
  34. V. G. Peters, D. R. Wyman, M. S. Patterson, G. L. Frank, “Optical properties of normal and diseased human breast tissues in the visible and near infrared,” Phys. Med. Biol. 35, 1317–1334 (1990). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited