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Applied Optics

Applied Optics


  • Vol. 36, Iss. 1 — Jan. 1, 1997
  • pp: 214–220

Three-dimensional tumor localization in thick tissue with the use of diffuse photon-density waves

Charles L. Matson, Natalie Clark, Lenore McMackin, and Janet S. Fender  »View Author Affiliations

Applied Optics, Vol. 36, Issue 1, pp. 214-220 (1997)

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A new approach to three-dimensional tumor localization in turbid media with the use of measurements in a single plane is presented. Optical diffuse photon-density waves are used to probe the turbid medium. Relative amplitudes and phases are measured in the detection plane. Lateral localization is accomplished in the detection plane. With a Fourier optics approach, the scattered wave is reconstructed throughout the volume to provide depth localization. Computer-simulation results that validate this technique are presented. Applications of this technique to multiple tumors and to optical mammography are discussed.

© 1997 Optical Society of America

Original Manuscript: March 4, 1996
Revised Manuscript: June 17, 1996
Published: January 1, 1997

Charles L. Matson, Natalie Clark, Lenore McMackin, and Janet S. Fender, "Three-dimensional tumor localization in thick tissue with the use of diffuse photon-density waves," Appl. Opt. 36, 214-220 (1997)

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