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Applied Optics

Applied Optics


  • Vol. 36, Iss. 22 — Aug. 1, 1997
  • pp: 5655–5661

Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties

Judith R. Mourant, Irving J. Bigio, Darren A. Jack, Tamara M. Johnson, and Heather D. Miller  »View Author Affiliations

Applied Optics, Vol. 36, Issue 22, pp. 5655-5661 (1997)

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The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the path length traveled by the collected light through the tissue depends on the scattering properties of the tissue. We demonstrate, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light-collection fibers the path length of the collected photons does not depend on scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, and inexpensive methods for measuring absorption changes in tissue.

© 1997 Optical Society of America

Original Manuscript: September 27, 1996
Revised Manuscript: December 23, 1996
Published: August 1, 1997

Judith R. Mourant, Irving J. Bigio, Darren A. Jack, Tamara M. Johnson, and Heather D. Miller, "Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties," Appl. Opt. 36, 5655-5661 (1997)

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