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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 36, Iss. 28 — Oct. 1, 1997
  • pp: 7277–7282

Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media

Lihong Wang and Xuemei Zhao  »View Author Affiliations


Applied Optics, Vol. 36, Issue 28, pp. 7277-7282 (1997)
http://dx.doi.org/10.1364/AO.36.007277


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Abstract

Continuous-wave ultrasonic modulation of scattered laser light was used to image objects buried in tissue-simulating turbid media. The buried object had an absorption coefficient greater than the background turbid medium. The ultrasonic wave that was focused into the turbid media modulated the laser light that passed through the ultrasonic field. The modulated laser light that was collected by a photomultiplier tube reflected the local mechanical and optical properties in the zone of ultrasonic modulation. Objects buried in the middle plane of 5-cm-thick dense turbid media were imaged with millimeter resolution through the scanning and detecting alterations of the ultrasound-modulated optical signal. The optical properties of the dense turbid media included an absorption coefficient of 0.1 cm-1 and a reduced scattering coefficient of 10 cm-1 and were comparable with those of biological tissues in the visible and near-IR ranges. The dependence of the ultrasound-modulated optical signal on the off-axis distance of the detector from the optic axis and the area of the detector was studied as well.

© 1997 Optical Society of America

History
Original Manuscript: January 10, 1997
Revised Manuscript: May 19, 1997
Published: October 1, 1997

Citation
Lihong Wang and Xuemei Zhao, "Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media," Appl. Opt. 36, 7277-7282 (1997)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-36-28-7277


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References

  1. See related studies in R. R. Alfano, J. G. Fujimoto, eds., Advances in Optical Imaging and Photon Migration, Vol. 2 of Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 1996).
  2. L. Wang, S. L. Jacques, “Application of probability of n scatterings of light passing through an idealized tissue slab in breast imaging,” in Advances in Optical Imaging and Photon Migration, R. R. Alfano, ed., Vol. 21 of OSA Proceedings Series, pp. 181–186.
  3. F. A. Marks, H. W. Tomlinson, G. W. Brooksby, “Comprehensive approach to breast cancer detection using light: photon localization by ultrasound modulation and tissue characterization by spectral discrimination,” in Photon Migration and Imaging in Random Media and Tissues, B. Chance, R. R. Alfano, eds., Proc. SPIE1888, 500–510 (1993). [CrossRef]
  4. L. Wang, S. L. Jacques, X. Zhao, “Continuous-wave ultrasonic modulation of scattered laser light to image objects in turbid media,” Opt. Lett. 20, 629–631 (1995). [CrossRef] [PubMed]
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  8. R. J. Farrell, M. S. Patterson, B. C. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19, 879–888 (1992). [CrossRef] [PubMed]
  9. L.-H. Wang, X. Zhao, S. L. Jacques, “Computation of the optical properties of tissues from light reflectance using a neural network,” in Laser-Tissue Interaction V, S. L. Jacques, ed., Proc. SPIE2134A, 391–399 (1994).
  10. J. W. Goodman, Statistical Optics (Wiley, New York, 1985).
  11. L. Wang, X. Zhao, S. L. Jacques, “Ultrasound-modulated optical tomography for thick tissue imaging,” in Photon Propagation in Tissues, B. Chance, D. T. Delpy, G. J. Mueller, eds., Proc. SPIE2626, 237–248, (1995). [CrossRef]
  12. A. Korpel, Acousto-Optics (Marcel Dekker, New York, 1988).

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