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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 37, Iss. 13 — May. 1, 1998
  • pp: 2755–2765

Localization of Luminescent Inhomogeneities in Turbid Media with Spatially Resolved Measurements of cw Diffuse Luminescence Emittance

Edward L. Hull, Michael G. Nichols, and Thomas H. Foster  »View Author Affiliations


Applied Optics, Vol. 37, Issue 13, pp. 2755-2765 (1998)
http://dx.doi.org/10.1364/AO.37.002755


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Abstract

We present a steady-state method for localizing a source ofluminescence (i.e., fluorescence or phosphorescence) buried in asemi-infinite turbid medium with unknown optical properties. Adiffusion theory expression describing the emittance of an isotropicpoint source is fit to spatially resolved surface measurements of thediffuse emittance from the luminescent source. The techniquereports the location of the center of a 6.0-mm-diameter, fluorophore-containing spherical bulb embedded in a liquid phantom withan accuracy of 1.0 mm or better for source depths as great as 40.0mm. Monte Carlo data are analyzed to investigate the range and thepossible sources of error in the reconstructed source depth.

© 1998 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(260.2510) Physical optics : Fluorescence
(260.3800) Physical optics : Luminescence
(300.2530) Spectroscopy : Fluorescence, laser-induced

Citation
Edward L. Hull, Michael G. Nichols, and Thomas H. Foster, "Localization of Luminescent Inhomogeneities in Turbid Media with Spatially Resolved Measurements of cw Diffuse Luminescence Emittance," Appl. Opt. 37, 2755-2765 (1998)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-37-13-2755

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