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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 37, Iss. 13 — May. 1, 1998
  • pp: 2788–2797

Optical scattering properties of soft tissue: a discrete particle model

Joseph M. Schmitt and Gitesh Kumar  »View Author Affiliations


Applied Optics, Vol. 37, Issue 13, pp. 2788-2797 (1998)
http://dx.doi.org/10.1364/AO.37.002788


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Abstract

We introduce a micro-optical model of soft biological tissue that permits numerical computation of the absolute magnitudes of its scattering coefficients. A key assumption of the model is that the refractive-index variations caused by microscopic tissue elements can be treated as particles with sizes distributed according to a skewed log-normal distribution function. In the limit of an infinitely large variance in the particle size, this function has the same power-law dependence as the volume fractions of the subunits of an ideal fractal object. To compute a complete set of optical coefficients of a prototypical soft tissue (single-scattering coefficient, transport scattering coefficient, backscattering coefficient, phase function, and asymmetry parameter), we apply Mie theory to a volume of spheres with sizes distributed according to the theoretical distribution. A packing factor is included in the calculation of the optical cross sections to account for correlated scattering among tightly packed particles. The results suggest that the skewed log-normal distribution function, with a shape specified by a limiting fractal dimension of 3.7, is a valid approximation of the size distribution of scatterers in tissue. In the wavelength range 600 ≤ λ ≤ 1400 nm, the diameters of the scatterers that contribute most to backscattering were found to be significantly smaller (λ/4–λ/2) than the diameters of the scatterers that cause the greatest extinction of forward-scattered light (3–4λ).

© 1998 Optical Society of America

OCIS Codes
(170.6930) Medical optics and biotechnology : Tissue
(290.0290) Scattering : Scattering
(350.4990) Other areas of optics : Particles

History
Original Manuscript: August 18, 1997
Revised Manuscript: December 2, 1997
Published: May 1, 1998

Citation
Joseph M. Schmitt and Gitesh Kumar, "Optical scattering properties of soft tissue: a discrete particle model," Appl. Opt. 37, 2788-2797 (1998)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-37-13-2788

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