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Applied Optics

Applied Optics


  • Vol. 38, Iss. 1 — Jan. 1, 1999
  • pp: 258–267

Optimum wavelength combinations for retinal vessel oximetry

Matthew H. Smith  »View Author Affiliations

Applied Optics, Vol. 38, Issue 1, pp. 258-267 (1999)

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Several investigators have demonstrated techniques for noninvasive measurement of the oxygen saturation of blood in retinal arteries and veins. These techniques have been based on measuring the optical density of a retinal vessel at multiple wavelengths and on calculating the oxygen saturation on the basis of the known absorption coefficients of hemoglobin and oxyhemoglobin. A technique is presented for determining the optimum wavelengths for retinal oximetry measurements. What is believed to be a novel wavelength combination of 488, 635, and 905 nm is found to provide excellent oxygen sensitivity across a broad range of typical vessel diameters and saturations. The use of this wavelength combination should allow for the most accurate retinal saturation measurements made to date.

© 1999 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(300.1030) Spectroscopy : Absorption

Original Manuscript: July 2, 1998
Revised Manuscript: October 9, 1998
Published: January 1, 1999

Matthew H. Smith, "Optimum wavelength combinations for retinal vessel oximetry," Appl. Opt. 38, 258-267 (1999)

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