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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 38, Iss. 16 — Jun. 1, 1999
  • pp: 3670–3680

Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance

Rinaldo Cubeddu, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, and Gianluca Valentini  »View Author Affiliations


Applied Optics, Vol. 38, Issue 16, pp. 3670-3680 (1999)
http://dx.doi.org/10.1364/AO.38.003670


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Abstract

We developed a compact dual-wavelength multichannel tissue oximeter based on the time-correlated single-photon counting (TCSPC) technique. The light sources are two pulsed diode lasers (output wavelengths of 672 and 818 nm, an average power of 1 mW, a pulse duration of 100 ps, and a pulse-repetition rate as high as 80 MHz). The time-resolved reflectance photons are detected by a multianode photomultiplier, and the output signals are redirected by a router to different memory blocks of the TCSPC personal computer board. The system’s accuracy in determining the absorption μ a and the reduced-scattering μ s ′ coefficients and in reconstructing absorber concentrations in diffusive media was tested on phantoms. Preliminary in vivo tissue-oxygenation measurements were performed on healthy volunteers under different physiological conditions with a minimum acquisition time of 100 ms and an injected power of less than 100 µW.

© 1999 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved

History
Original Manuscript: November 9, 1998
Revised Manuscript: February 26, 1999
Published: June 1, 1999

Citation
Rinaldo Cubeddu, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, and Gianluca Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance," Appl. Opt. 38, 3670-3680 (1999)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-38-16-3670


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