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Applied Optics

Applied Optics


  • Vol. 38, Iss. 22 — Aug. 1, 1999
  • pp: 4914–4929

Triangulation method for determining capillary blood flow and physical characteristics of the skin

Sridhar Gorti, Hiroshi Tone, and Genji Imokawa  »View Author Affiliations

Applied Optics, Vol. 38, Issue 22, pp. 4914-4929 (1999)

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A method capable of measuring blood flow at precise depths within the skin is described. The method determines the static and the dynamic properties of light that is backscattered to small areas on the surface of the skin at several contiguous locations along the expected trajectory of laser-light propagation. From observations the method has been shown to be capable of determining physical characteristics that are unique to the different layers of the skin.

© 1999 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

Original Manuscript: December 4, 1998
Revised Manuscript: April 20, 1999
Published: August 1, 1999

Sridhar Gorti, Hiroshi Tone, and Genji Imokawa, "Triangulation method for determining capillary blood flow and physical characteristics of the skin," Appl. Opt. 38, 4914-4929 (1999)

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  1. A. M. A. Schabauer, T. W. Rooke, “Cutaneous laser Doppler flowmetry: application and findings,” Mayo Clin. Proc. 69, 564–574 (1994). [CrossRef] [PubMed]
  2. M. D. Stern, “In vivo evaluation of microcirculation by coherent light scattering,” Nature 254, 56–58 (1975). [CrossRef] [PubMed]
  3. T. Tanaka, G. B. Benedek, “Measurement of the velocity of blood flow (in vivo) using a fiber optic catheter and optical mixing spectroscopy,” Appl. Opt. 14, 189–196 (1975). [CrossRef] [PubMed]
  4. D. W. Stepnick, R. E. Hayden, “Postoperative monitoring and salvage of microvascular free flaps,” Reconstr. Mandible Oropharynx 27, 1201–1217 (1994).
  5. H. Svenson, P. Svedman, J. Holmberg, S. Jacobsson, “Detecting arterial and venous obstruction in flaps,” Ann. Plast. Surg. 14, 20–23 (1985). [CrossRef]
  6. H. Schliephake, R. Schnelzeisen, F. W. Neukam, “Long-term results of blood flow and cutaneous sensibility of flaps used for the reconstruction of facial soft tissues,” J. Oral Maxillofac. Surg. 52, 1247–1252 (1994). [CrossRef] [PubMed]
  7. H. Fujii, K. Nohira, Y. Yamamoto, H. Ikawa, T. Ohura, “Evaluation of blood flow by laser speckle image sensing. Part I,” Appl. Opt. 26, 5321–5325 (1987). [CrossRef] [PubMed]
  8. K. Wårdell, A. Jakobsson, G. Nilsson, “Laser Doppler perfusion imaging by dynamic light scattering,” IEEE Trans. Biomed. Eng. 40, 309–316 (1993). [CrossRef] [PubMed]
  9. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22, 1439–1441 (1997). [CrossRef]
  10. Z. Chen, T. E. Milner, X. Wang, S. Srinivas, J. S. Nelson, “Optical Doppler tomography: imaging in vivo blood flow dynamics following pharacological intervention and photodynamic therapy,” Photochem. Photobiol. 67, 56–60 (1998). [CrossRef] [PubMed]
  11. S. Gorti, “An apparatus and method for measuring blood flow at precise depths in tissue or skin, and the thickness and elasticity of region(s) within tissue or skin,” U.S. patent pending. (submitted 23March1997).
  12. R. Bonner, R. Nossal, “Model for laser Doppler measurements of blood flow in tissue,” Appl. Opt. 20, 2097–2107 (1981). [CrossRef] [PubMed]
  13. R. L. Fante, “Propagation of electromagnetic waves through turbulent plasma using transport theory,” IEEE Trans. Antennas Propag. AP-21, 750–755 (1973). [CrossRef]
  14. A. Ishimaru, “Diffusion of light in turbid material,” Appl. Opt. 28, 2210–2215 (1989). [CrossRef] [PubMed]
  15. W. A. G. Bruls, J. C. van der Leun, “Forward scattering properties of human epidermal layers,” Photochem. Photobiol. 40, 231–242 (1984). [CrossRef] [PubMed]
  16. W. A. G. Bruls, H. Slaper, J. C. van der Leun, L. Berrens, “Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths,” Photochem. Photobiol. 40, 485–494 (1984). [CrossRef] [PubMed]
  17. Y. Kuga, A. Ishimaru, “Backscattering enhancement by randomly distributed very large particles,” Appl. Opt. 28, 2165–2169 (1989). [CrossRef] [PubMed]
  18. Z.-H. Gu, J. Q. Lu, A. A. Maradudin, A. Martinez, E. R. Mendez, “Coherence in the single and multiple scattering of light from randomly rough surfaces,” Appl. Opt. 32, 2852–2859 (1993). [CrossRef] [PubMed]
  19. S. Gorti, A. Kiba, “Noninvasive thickness measurement of stratum corneum by light scattering spectroscopy,” J. Soc. Cosmet. Chem. Jpn. 27, 374–382 (1993). [CrossRef]
  20. B. J. Berne, R. Pecora, Dynamic Light Scattering (Wiley, New York, 1976).
  21. E. Jakeman, C. J. Oliver, E. R. Pike, “The effects of spatial coherence of intensity fluctuation distribution of Gaussian light,” J. Phys. A 3, L45–L48 (1970). [CrossRef]
  22. C. Kittel, Elementary Statistical Physics (Wiley, New York, 1958), pp. 133–140.
  23. J. M. Schmitt, S. H. Xiang, “Cross-polarized backscatter in optical coherence tomography of biological tissue,” Opt. Lett. 23, 1060–1062 (1998). [CrossRef]
  24. F. P. Bolin, L. E. Preuss, R. C. Taylor, R. J. Ference, “Refractive index of some mammalian tissues using a fiber optic cladding method,” Appl. Opt. 28, 2297–2303 (1989). [CrossRef] [PubMed]
  25. D. J. Pine, D. A. Weitz, J. X. Zhu, E. Herbolzheimer, “Diffusing-wave spectroscopy: dynamic light scattering in the multiple scattering limit,” J. Phys. France 51, 2101–2127 (1990). [CrossRef]
  26. T. Tanaka, “Light scattering from polymer gels,” in Dynamic Light Scattering, R. Pecora, ed. (Plenum, New York, 1985), pp. 347–362. [CrossRef]
  27. H. Svensson, P. Svedman, J. Holmberg, J. B. Wieslander, “Detecting changes in arterial and venous blood flow in flaps,” Ann. Plast. Surg. 15, 35–40 (1985). [CrossRef] [PubMed]

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