Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Concentration measurements of multiple analytes in human sera by near-infrared laser Raman spectroscopy

Not Accessible

Your library or personal account may give you access

Abstract

Our primary goal in this study is to demonstrate that near-infrared Raman spectroscopy is feasible as a rapid and reagentless analytic method for clinical diagnostics. Raman spectra were collected on human sera by use of a 785-nm excitation laser and a single-stage holographic spectrometer. A partial-least-squares method was used to predict the analyte concentrations of interest. The prediction errors of total protein, albumin, triglyceride, and glucose in human sera ranged from 1.0% to 10%, which are highly acceptable for clinical diagnosis, of their mean physiological levels. For investigating the potential application of near-infrared Raman spectroscopy in screening of therapeutical drugs and substances of abuse the concentrations of acetaminophen, ethanol, and codeine in water solution were measured in the same fashion. The errors of the Raman tests for acetaminophen and ethanol are lower than their toxic levels in human serum, and the sensitivity for detection of codeine fails to reach its toxic level.

© 1999 Optical Society of America

Full Article  |  PDF Article
More Like This
Multicomponent blood analysis by near-infrared Raman spectroscopy

Andrew J. Berger, Tae-Woong Koo, Irving Itzkan, Gary Horowitz, and Michael S. Feld
Appl. Opt. 38(13) 2916-2926 (1999)

Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy

Andrew J. Berger, Yang Wang, and Michael S. Feld
Appl. Opt. 35(1) 209-212 (1996)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved