The narrowing effects of scatterers on the lifetime and the spectral width of the laser-induced fluorescence of organic dyes hosted in poly(methyl methacrylate) polymer sheets were studied. The excitation source was a distributed-feedback dye laser emitting 0.5-ps pulses at 496 nm. Spectral and temporal features were recorded simultaneously on a spectrograph–streak-camera detection system. The results were then compared with those obtained from dye solutions in methanol that were recorded in previous studies. The effects of the different host environments on the fluorescence characteristics of the dye were thus investigated. These effects are currently studied when the dye is inserted into human tissue in an attempt to boost tumor detection and photodynamic-therapy efficiency. Some initial results are presented.
© 1999 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.7050) Medical optics and biotechnology : Turbid media
Giannis Zacharakis, George Heliotis, George Filippidis, Demetrios Anglos, and Theodore G. Papazoglou, "Investigation of the Laserlike Behavior of Polymeric Scattering Gain Media Under Subpicosecond Laser Excitation," Appl. Opt. 38, 6087-6092 (1999)