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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 38, Iss. 7 — Mar. 1, 1999
  • pp: 1259–1272

Measurement of tissue absorption coefficients by use of interferometric photothermal spectroscopy

Andrew D. Yablon, Norman S. Nishioka, Bora B. Mikić, and Vasan Venugopalan  »View Author Affiliations


Applied Optics, Vol. 38, Issue 7, pp. 1259-1272 (1999)
http://dx.doi.org/10.1364/AO.38.001259


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Abstract

We describe a spectroscopic technique called interferometric photothermal spectroscopy (IPTS) that can measure the absorption coefficient of pulsed laser radiation in nonscattering tissue samples. The technique is suitable for measuring effective absorption coefficients from 103 to 105 cm-1. IPTS is particularly attractive because it requires minimal disturbance of the sample. These features indicate potential use for in vivo measurements of tissue absorption coefficients. To validate the technique, the absorption coefficient of pulsed Q-switched Er:YSGG (2.79-µm) radiation in pure water was measured to be 5200 (±500) cm-1 when IPTS was used, in agreement with other published values. IPTS was also used to measure the absorption coefficient of pulsed ArF excimer laser radiation (193 nm) in bovine corneal stroma (in vitro), giving a value of 1.9 (±0.4) × 104 cm-1.

© 1999 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.4290) Instrumentation, measurement, and metrology : Nondestructive testing
(120.6810) Instrumentation, measurement, and metrology : Thermal effects
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6930) Medical optics and biotechnology : Tissue
(300.6430) Spectroscopy : Spectroscopy, photothermal

History
Original Manuscript: June 30, 1998
Revised Manuscript: November 9, 1998
Published: March 1, 1999

Citation
Andrew D. Yablon, Norman S. Nishioka, Bora B. Mikić, and Vasan Venugopalan, "Measurement of tissue absorption coefficients by use of interferometric photothermal spectroscopy," Appl. Opt. 38, 1259-1272 (1999)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-38-7-1259

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