Fiber-optic evanescent-wave spectroscopy and neural networks: application to chemical blood analysis

Osnat Eytan; Ben-Ami Sela; Abraham Katzir

doi:10.1364/AO.39.003357

Applied Optics
Vol. 39,
Issue 19,
pp. 3357-3360
(2000)
•https://doi.org/10.1364/AO.39.003357

Fiber-optic evanescent-wave spectroscopy and neural networks: application to chemical blood analysis

Osnat Eytan, Ben-Ami Sela, and Abraham Katzir

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Osnat Eytan, Ben-Ami Sela, and Abraham Katzir, "Fiber-optic evanescent-wave spectroscopy and neural networks: application to chemical blood analysis," Appl. Opt. 39, 3357-3360 (2000)

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Abstract

An infrared spectral analysis of human blood serum has been carried out with Fourier transform infrared fiber-optic evanescent-wave spectroscopy. The measured spectra were analyzed by neural network analysis to predict concentrations of cholesterol, creatinine, total protein, urea, and uric acid. The predicted concentrations were compared with results from standard chemical analysis of blood and a good correlation was observed.

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Blood Constituent	Database		60 Samples
Blood Constituent	C _min-C _max	C _a	C _min-C _max	C _a
Cholesterol (mg/dl)	38–391	175.3812	44–343	194.90
Creatinine (mg/dl)	0.5–13.5	1.6204	0.6–13.5	1.9133
Total protein (g/dl)	3.2–9.8	6.0403	4.2–7.6	6.0
Urea (mg/dl)	4–205	45.4530	6–180	50.0833
Uric acid (mg/dl)	1.2–12.8	5.2497	2.3–11.1	5.5800

Blood Constituent	σ	PRESS^1/2/C _a
Cholesterol (mg/dl)	0.1275	0.0225
Creatinine (mg/dl)	0.1644	0.1675
Total protein (g/dl)	0.0604	0.0272
Urea (mg/dl)	0.1711	0.0932
Uric acid (mg/dl)	0.1290	0.0281

Blood Constituent	C _min-C _max	C _a	σ	PRESS^1/2/C_a
Cholesterol (mg/dl)	83–343	197.55	0.0446	0.405
Creatinine (mg/dl)	0.6–8.2	1.86	0.1263	1.4223
Total protein (g/dl)	4.2–7.1	5.83	9.1177	0.1904
Urea (mg/dl)	13–165	55.1	0.0923	0.7740
Uric acid (mg/dl)	1.8–10.2	5.355	0.1114	0.4235

Blood Constituent	Database		60 Samples
Blood Constituent	C _min-C _max	C _a	C _min-C _max	C _a
Cholesterol (mg/dl)	38–391	175.3812	44–343	194.90
Creatinine (mg/dl)	0.5–13.5	1.6204	0.6–13.5	1.9133
Total protein (g/dl)	3.2–9.8	6.0403	4.2–7.6	6.0
Urea (mg/dl)	4–205	45.4530	6–180	50.0833
Uric acid (mg/dl)	1.2–12.8	5.2497	2.3–11.1	5.5800

Blood Constituent	σ	PRESS^1/2/C _a
Cholesterol (mg/dl)	0.1275	0.0225
Creatinine (mg/dl)	0.1644	0.1675
Total protein (g/dl)	0.0604	0.0272
Urea (mg/dl)	0.1711	0.0932
Uric acid (mg/dl)	0.1290	0.0281

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Applied Optics