OSA's Digital Library

Applied Optics

Applied Optics


  • Vol. 39, Iss. 25 — Sep. 1, 2000
  • pp: 4721–4729

Near-infrared spectroscopy of the adult head: effect of scattering and absorbing obstructions in the cerebrospinal fluid layer on light distribution in the tissue

Hamid Dehghani and David T. Delpy  »View Author Affiliations

Applied Optics, Vol. 39, Issue 25, pp. 4721-4729 (2000)

View Full Text Article

Enhanced HTML    Acrobat PDF (508 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Previous modeling of near-infrared (NIR) light distribution in models of the adult head incorporating a clear nonscattering cerebrospinal fluid (CSF) layer have shown the latter to have a profound effect on the resulting photon measurement density function (PMDF). In particular, the presence of the CSF limits the PMDF largely to the outer cortical gray matter with little signal contribution from the deeper white matter. In practice, the CSF is not a simple unobstructed clear layer but contains light-scattering membranes and is crossed by various blood vessels. Using a radiosity-diffusion finite-element model, we investigated the effect on the PMDF of introducing intrusions within the clear layer. The results show that the presence of such obstructions does not significantly increase the light penetration into the brain tissue, except immediately adjacent to the obstruction and that its presence also increases the light sampling of the adjacent skull tissues, which would lead to additional contamination of the NIR spectroscopy signal by the surface tissue layers.

© 2000 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(300.6340) Spectroscopy : Spectroscopy, infrared

Original Manuscript: January 11, 2000
Revised Manuscript: May 16, 2000
Published: September 1, 2000

Hamid Dehghani and David T. Delpy, "Near-infrared spectroscopy of the adult head: effect of scattering and absorbing obstructions in the cerebrospinal fluid layer on light distribution in the tissue," Appl. Opt. 39, 4721-4729 (2000)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. J. E. Brazy, D. V. Lewis, M. H. Mitnick, F. F. Jobsis vander Vliet, “Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations,” Pediatrics 25, 217–225 (1985).
  2. J. S. Wyatt, D. T. Delpy, M. Cope, S. Wray, E. O. R. Reynolds, “Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectroscopy,” Lancet ii, 1063–1066 (1986).
  3. M. Ferrari, E. Zanette, I. Giannini, G. Sideri, C. Fieschi, A. Carpi, “Effect of cartid artery compression test on regional cerebral blood volume, haemoglobin oxygen saturation and cytochrome-c-oxidase redox level in cerebrovascular patients,” Adv. Exp. Med. Biol. 200, 213–222 (1986). [CrossRef]
  4. N. B. Hampson, E. M. Camporesi, B. W. Stolp, R. E. Moon, J. E. Shook, J. A. Griebel, C. A. Piantadosi, “Cerebral oxygen availability by NIR spectroscopy during transient hypoxia in humans,” J. Appl. Physiol. 69, 907–913 (1990). [PubMed]
  5. Y. Hoshi, M. Tamura, “Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man,” Neurosci. Lett. 150, 5–8 (1993). [CrossRef] [PubMed]
  6. S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, E. O. R. Reynolds, “Characterisation of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non invasive monitoring of cerebral oxygenation,” Biochem. Biophys. Acta 933, 184–192 (1988).
  7. E. Okada, M. Firbank, M. Schweiger, S. R. Arridge, M. Cope, D. T. Delpy, “Theoretical and experimental investigation of near infrared light propagation in a model of the adult head,” Appl. Opt. 36, 21–31 (1997). [CrossRef] [PubMed]
  8. H. Liu, D. A. Boas, A. G. Yodh, B. Chance “Influence of clear cerebrospinal fluid on NIR brain imaging and cerebral oxygenation monitoring,” in Advances in Optical Imaging and Photon Migration, R. R. Alfano, James G. Fujimoto, eds. Vol. 2 of OSA Trends in Optics and Photonics (Optical Society of America, Washington, D.C., 1996), pp. 372–375.
  9. M. Firbank, S. R. Arridge, M. Schweiger, D. T. Delpy, “An investigation of light transport through scattering bodies with non-scattering regions,” Phys. Med. Biol. 41, 767–783 (1996). [CrossRef] [PubMed]
  10. A. H. Hielscher, R. E. Alcouffe, R. L. Barbour, “Transport and diffusion calculations on MRI-generated data,” in Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, B. Chance, R. R. Alfano, eds., Proc. SPIE2979, 500–508 (1997).
  11. S. R. Arridge, H. Dehghani, M. Schweiger, E. Okada, “The finite element model for the propagation of light in scattering media: a direct method for domains with non-scattering regions,” Med. Phys. 27, 252–264 (2000). [CrossRef] [PubMed]
  12. H. Dehghani, D. T. Delpy, S. R. Arridge, “Photon migration in non-scattering tissue and the effects on image reconstruction,” Phys. Med. Biol. 44, 2897–2906 (1999). [CrossRef]
  13. A. H. Hielscher, R. E. Alcouffe, R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissue,” Phys. Med. Biol. 43, 1285–1302 (1998). [CrossRef] [PubMed]
  14. M. Firbank, E. Okada, D. T. Delpy, “A theoretical study of the signal contribution of regions of the adult head to near infrared spectroscopy studies of visual evoked responses,” Neuroimag. 8, 69–78 (1998). [CrossRef]
  15. R. A. J. Groenhuis, H. A. Ferwada, J. J. Ten Bosch, “Scattering and absorption of turbid materials determined from reflection measurements. 1. Theory,” Appl. Opt. 22, 2456–2462 (1983); “Scattering and absorption of turbid materials determined from reflection measurements. 2. Measuring method and callibration,” Appl. Opt. 22, 2463–2467 (1983). [CrossRef] [PubMed]
  16. T. Nakai, G. Nishimura, K. Yamamoto, M. Tamura, “Expression of optical diffusion coefficient in high-absorption turbid media,” Phys. Med. Biol. 42, 2541–2549 (1997). [CrossRef]
  17. M. Bassani, F. Martelli, G. Zaccanti, D. Contini, “Independence of the diffusion coefficient from absorption: experimental and numerical evidence,” Opt. Lett. 22, 853–855 (1997). [CrossRef] [PubMed]
  18. M. F. Cohen, J. R. Wallace, Radiosity and Realistic Image Synthesis (Academic, London, 1993).
  19. S. R. Arridge, M. Schweiger, “Photon-measurement density functions. II. Finite-element-method calculations,” Appl. Opt. 34, 8026–8037 (1995). [CrossRef] [PubMed]
  20. S. R. Arridge, M. Schweiger, M. Hiraoka, D. T. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299–309 (1993). [CrossRef] [PubMed]
  21. M. Schweiger, S. R. Arridge, M. Hiraoka, D. T. Delpy, “The finite element model for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779–1792 (1995). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited