Interferometric Sensor for Detection of Surface-Bound Bioreactions
Applied Optics, Vol. 39, Issue 34, pp. 6396-6405 (2000)
http://dx.doi.org/10.1364/AO.39.006396
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Abstract
An integrated optical interferometer for direct detection of affinity reactions is presented. A modern version of a Young’s interferometer is built with a waveguide structure as beam splitter and as sensing element. Resistive waveguides were produced by plasma-enhanced chemical vapor deposition of silicon oxinitride. At the output of this device a fringe pattern is detected by a CCD line camera. The adsorption of molecules on top of the waveguides is observed with a detection limit of 750 fg/mm2. The resolvable variation of effective refractive index is 9 × 10−8.
© 2000 Optical Society of America
[Optical Society of America ]
OCIS Codes
(130.6010) Integrated optics : Sensors
(130.6750) Integrated optics : Systems
(230.3120) Optical devices : Integrated optics devices
(230.7380) Optical devices : Waveguides, channeled
Citation
Albrecht Brandenburg, Ralf Krauter, Christa Künzel, Monika Stefan, and Heinrich Schulte, "Interferometric Sensor for Detection of Surface-Bound Bioreactions," Appl. Opt. 39, 6396-6405 (2000)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-39-34-6396
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