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Applied Optics

Applied Optics


  • Vol. 39, Iss. 34 — Dec. 1, 2000
  • pp: 6508–6514

Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source–detector separation

Murat Canpolat and Judith R. Mourant  »View Author Affiliations

Applied Optics, Vol. 39, Issue 34, pp. 6508-6514 (2000)

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We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source–detector separation; therefore the measurements could be performed through the working channel of an endoscope.

© 2000 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5180) Medical optics and biotechnology : Photodynamic therapy

Original Manuscript: June 8, 2000
Revised Manuscript: August 28, 2000
Published: December 1, 2000

Murat Canpolat and Judith R. Mourant, "Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source–detector separation," Appl. Opt. 39, 6508-6514 (2000)

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