We report measurement of optical transport parameters of normal and malignant (ductal carcinoma) human breast tissue. A spatially resolved steady-state diffuse reflectance technique was used for measurement of the reduced scattering coefficient (μ<sub><i>s</i></sub>′) and the absorption coefficient (μ<sub><i>a</i></sub>) of the tissue. The anisotropy parameter of scattering (<i>g</i>) was estimated by goniophotometric measurements of the scattering phase function. The values of μ<sub><i>s</i></sub>′ and μ<sub><i>a</i></sub> for malignant breast tissue were observed to be larger than those for normal breast tissue over the wavelength region investigated (450–650 nm). Further, by using both the diffuse reflectance and the goniophotometric measurements, we estimated the Mie equivalent average radius of tissue scatterers to be larger in malignant tissue than in normal tissue.
© 2001 Optical Society of America
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media
N. Ghosh, S. K. Mohanty, S. K. Majumder, and P. K. Gupta, "Measurement of Optical Transport Properties of Normal and Malignant Human Breast Tissue," Appl. Opt. 40, 176-184 (2001)