OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 40, Iss. 1 — Jan. 1, 2001
  • pp: 176–184

Measurement of optical transport properties of normal and malignant human breast tissue

N. Ghosh, S. K. Mohanty, S. K. Majumder, and P. K. Gupta  »View Author Affiliations


Applied Optics, Vol. 40, Issue 1, pp. 176-184 (2001)
http://dx.doi.org/10.1364/AO.40.000176


View Full Text Article

Enhanced HTML    Acrobat PDF (145 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report measurement of optical transport parameters of normal and malignant (ductal carcinoma) human breast tissue. A spatially resolved steady-state diffuse reflectance technique was used for measurement of the reduced scattering coefficient (μ s ′) and the absorption coefficient (μ a ) of the tissue. The anisotropy parameter of scattering (g) was estimated by goniophotometric measurements of the scattering phase function. The values of μ s ′ and μ a for malignant breast tissue were observed to be larger than those for normal breast tissue over the wavelength region investigated (450–650 nm). Further, by using both the diffuse reflectance and the goniophotometric measurements, we estimated the Mie equivalent average radius of tissue scatterers to be larger in malignant tissue than in normal tissue.

© 2001 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

History
Original Manuscript: April 25, 2000
Revised Manuscript: September 18, 2000
Published: January 1, 2001

Citation
N. Ghosh, S. K. Mohanty, S. K. Majumder, and P. K. Gupta, "Measurement of optical transport properties of normal and malignant human breast tissue," Appl. Opt. 40, 176-184 (2001)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-40-1-176


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. J. Welch, M. J. C. Van Germert, W. M. Star, B. C. Wilson, “Overview of tissue optics,” in Optical Thermal Response of Laser Irradiated Tissue, A. J. Welch, M. J. C. Van Germert, eds. (Plenum, New York, 1995), Chap. 2.
  2. C. F. Bohren, D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).
  3. R. A. J. Groenhuis, H. A. Ferwerda, J. J. Ten Bosch, “Scattering and absorption of turbid meterials determined from reflection measurements. 1. Theory,” Appl. Opt. 22, 2456–2462 (1983). [CrossRef] [PubMed]
  4. R. A. J. Groenhuis, H. A. Ferwerda, J. J. Ten Bosch, “Scattering and absorption of turbid meterials determined from reflection measurements. 2. Measuring method and calibration,” Appl. Opt. 22, 2463–2467 (1983). [CrossRef] [PubMed]
  5. J. M. Steinke, A. P. Shepherd, “Diffuse reflectance of whole blood: model for a diverging light beam,” IEEE Trans. Biomed. Eng. 34, 826–833 (1986).
  6. B. C. Wilson, T. J. Farrell, M. S. Patterson, “An optical fiber-based diffuse reflectance spectrometer for non-invasive investigation of photodynamic sensitizers in vivo,” in Future Directions and Application in Photodynamic Therapy, G. J. Gomer, ed., Vol. IS06 of SPIE Institute Series (Society of Photo-Optical Instrumentation Engineers, Bellingham, Wash., 1990), pp. 219–231.
  7. J. M. Schmitt, G. X. Zhou, E. C. Walker, R. T. Wall, “Multilayer model of photon diffusion in skin,” J. Opt. Soc. Am. A 7, 2141–2153 (1990). [CrossRef] [PubMed]
  8. T. J. Farrell, M. S. Patterson, B. C. Wilson, “A diffusion theory model of spatially resolved steady state diffuse reflectance for the noninvasive determination of tissue optical properties in-vivo,” Med Phys. 19, 879–888 (1992). [CrossRef] [PubMed]
  9. R. C. Haskell, L. O. Svaasand, T. T. Tsay, T. C. Feng, M. McAdams, B. J. Tromberg, “Boundary conditions for the diffusion equation in radiative transfer,” J. Opt. Soc. Am. A 11, 2727–2741 (1994). [CrossRef]
  10. A. Kienle, M. S. Patterson, “Improved solution of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium,” J. Opt. Soc. Am. A 14, 246–254 (1997). [CrossRef]
  11. A. Ishimaru, “Diffusion approximation,” in Wave Propagation and Scattering in Random Media (Academic, New York, 1978), Vol. 1, Chap. 9, pp. 175–186. [CrossRef]
  12. F. Bevilacqua, D. Piguet, P. Marquet, J. D. Gross, B. J. Tromberg, C. Depeursinge, “In vivo local determination of tissue optical properties: applications to human brain,” Appl. Opt. 38, 4939–4950 (1999). [CrossRef]
  13. R. Marchesini, A. Bertoni, S. Andreola, E. Melloni, A. E. Sichirollo, “Extinction and absorption coefficients and scattering phase functions of human tissues in vitro,” Appl. Opt. 28, 2318–2324 (1989). [CrossRef] [PubMed]
  14. J. R. Mourant, T. Furelier, J. Boyer, T. M. Jhonson, I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms,” Appl. Opt. 36, 949–957 (1997). [CrossRef] [PubMed]
  15. A. M. K. Nilsson, C. Sturessen, D. L. Liu, S. Andersson-Engles, “Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermo therapy,” Appl. Opt. 37, 1256–1267 (1998). [CrossRef]
  16. J. R. Mourant, J. P. Frayer, A. H. Hielscher, A. A. Eick, D. Shen, T. M. Jhonson, “Mechanism of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics,” Appl. Opt. 37, 3586–3593 (1998). [CrossRef]
  17. V. C. Peters, D. R. Wyman, M. S. Ptterson, G. L. Frank, “Optical properties of normal and diseased human breast tissues in the visible and infrared,” Phys. Med. Biol. 35, 1317–1334 (1990). [CrossRef] [PubMed]
  18. A. J. Welch, M. J. C. Van Gemert, eds. Optical–Thermal Response of Laser-Irradiated Tissue (Plenum, New York, 1995), pp. 284–285.
  19. T. L. Troy, D. L. Page, E. M. Sevick-Muraca, “Optical properties of normal and diseased breast tissues: prognosis for optical mammography,” J. Biomed. Opt. 1, 342–355 (1996). [CrossRef] [PubMed]
  20. B. J. Tromberg, O. Coquoz, J. B. Fishkin, T. Pham, E. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan, D. Pham, “Non-invasive measurements of breast tissue optical properties using frequency domain photon migration,” Phil. Trans. R. Soc. London Ser. B 352, 661–668 (1997). [CrossRef]
  21. B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2, 26–40 (2000). [CrossRef] [PubMed]
  22. M. J. Holboke, B. J. Tromberg, X. Li, N. Sha, J. Fishkin, D. Kidney, J. Bulter, B. Chance, A. G. Yodh, “Three dimensional diffuse optical mammography with ultrasound localization in a human subject,” J. Biomed. Opt. 5, 237–247 (2000). [CrossRef] [PubMed]
  23. S. Fantini, S. A. Walker, M. A. Franceschini, M. Kaschke, P. M. Schlag, K. T. Moesta, “Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods,” Appl. Opt. 37, 1982–1989 (1998). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited