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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 40, Iss. 22 — Aug. 1, 2001
  • pp: 3800–3809

Optoacoustic tomography: time-gated measurement of pressure distributions and image reconstruction

Kornel P. Köstli, Martin Frenz, Heinz P. Weber, Günther Paltauf, and Heinz Schmidt-Kloiber  »View Author Affiliations


Applied Optics, Vol. 40, Issue 22, pp. 3800-3809 (2001)
http://dx.doi.org/10.1364/AO.40.003800


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Abstract

Optoacoustic imaging is a potential novel medical imaging technology to image structures in turbid media to depths of several millimeters with a resolution of some tens of micrometers. Thereby short laser pulses generate thermoelastic pressure waves inside a tissue, which are detected on the surface with a wideband ultrasonic transducer. Image reconstruction has the goal of calculating the distribution of the absorbing structures in the tissue. We present a method in which the acoustic field distribution is captured as a two-dimensional snapshot at the sample surface, using an optical-reflectance-based detection principle with a detection resolution of 20 µm. A new image reconstruction is accomplished by backprojection of the detected two-dimensional pressure distributions into the sample volume by use of the delay between the laser pulse and the time the snapshot was taken. Two-dimensional pressure-wave distribution and image reconstruction are demonstrated by simulations and experiments, in which small objects are irradiated with laser pulses of 6-ns duration. The method opens the possibility to irradiate the sample hidden in a light-scattering medium directly through the detector plane, thus enabling front-surface detection of the optoacoustic signals, which is especially important if structures close to the tissue surface have to be imaged. Reconstructed tomography images with a depth resolution of 20 µm and a lateral resolution of 200 µm are presented.

© 2001 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.6960) Imaging systems : Tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

History
Original Manuscript: October 17, 2000
Revised Manuscript: March 26, 2001
Published: August 1, 2001

Citation
Kornel P. Köstli, Martin Frenz, Heinz P. Weber, Günther Paltauf, and Heinz Schmidt-Kloiber, "Optoacoustic tomography: time-gated measurement of pressure distributions and image reconstruction," Appl. Opt. 40, 3800-3809 (2001)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-40-22-3800

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