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Applied Optics

Applied Optics


  • Vol. 40, Iss. 34 — Dec. 1, 2001
  • pp: 6367–6380

Simultaneous Near-Infrared Diffusive Light and Ultrasound Imaging

Nan Guang Chen, Puyun Guo, Shikui Yan, Daqing Piao, and Quing Zhu  »View Author Affiliations

Applied Optics, Vol. 40, Issue 34, pp. 6367-6380 (2001)

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We have constructed a near-real-time combined imager suitable for simultaneous ultrasound and near-infrared diffusive light imaging and coregistration. The imager consists of a combined hand-held probe and the associated electronics for data acquisition. A two-dimensional ultrasound array is deployed at the center of the combined probe, and 12 dual-wavelength laser source fibers (780 and 830 nm) and 8 optical detector fibers are deployed at the periphery. We have experimentally evaluated the effects of missing optical sources in the middle of the combined probe on the accuracy of the reconstructed optical absorption coefficient and assessed the improvements of a reconstructed absorption coefficient with the guidance of the coregistered ultrasound. The results have shown that, when the central ultrasound array area is in the neighborhood of 2 cm × 2 cm, which corresponds to the size of most commercial ultrasound transducers, the optical imaging is not affected. The results have also shown that the iterative inversion algorithm converges quickly with the guidance of a priori three-dimensional target distribution, and only one iteration is needed to reconstruct an accurate optical absorption coefficient.

© 2001 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3830) Medical optics and biotechnology : Mammography
(170.5270) Medical optics and biotechnology : Photon density waves
(170.7170) Medical optics and biotechnology : Ultrasound

Nan Guang Chen, Puyun Guo, Shikui Yan, Daqing Piao, and Quing Zhu, "Simultaneous Near-Infrared Diffusive Light and Ultrasound Imaging," Appl. Opt. 40, 6367-6380 (2001)

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  1. T. A. Stavros, D. Thickman, and C. Rapp, “Solid breast nodules: use of sonography to distinguish between benign and malignant lesions,” Radiology 196, 123–134 (1995).
  2. G. Rahbar, A. C. Sie, G. C. Hansen, J. S. Prince, M. L. Melany, H. Reynolds, V. P. Jackson, J. W. Sayre, and L. W. Bassett, “Benign versus malignant solid breast masses: US differentiation,” Radiology 213, 889–894 (1999).
  3. V. P. Jackson, “The current role of ultrasonography in breast imaging,” Radiol. Clin. North Am. 33, 1161–1170 (1995).
  4. B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2, 26–40 (2000).
  5. S. Fantini, S. Walker, M. Franceschini, M. Kaschke, P. Schlag, and K. Moesta, “Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods,” Appl. Opt. 37, 1982–1989 (1998).
  6. S. M. Nioka, M. Shnall, M. Miwa, S. Orel, M. Haida, S. Zhao, and B. Chance, “Photon imaging of human breast cancer,” Adv. Exp. Med. Biol. 16, 171–179 (1994).
  7. R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, “Regional imager for low resolution functional imaging of the brain with diffusing near-infrared light,” Photochem. Photobiol. 67, 33–40 (1998).
  8. T. McBride, B. W. Pogue, E. Gerety, S. Poplack, U. Osterberg, B. Pogue, and K. Paulsen, “Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue,” Appl. Opt. 38, 5480–5490 (1999).
  9. M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, “Frequency-domain techniques enhance optical mammography: initial clinical results,” Proc. Natl. Acad. Sci. USA 94, 6468–6473 (1997).
  10. J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, “Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject,” Appl. Opt. 36, 10–20 (1997).
  11. T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, “Optical properties of normal and diseased breast tissues: prognosis for optical mammography,” J. Biomed. Opt. 1, 342–355 (1996).
  12. R. J. Grable, D. P. Rohler, and S. Kla, “Optical tomography breast imaging,” in Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, B. Chance and R. Alfano, eds., Proc. SPIE 2979, 197–210 (1997).
  13. Y. Yao, Y. Wang, Y. Pei, W. Zhu, and R. L. Barbour, “Frequency-domain optical imaging of absorption and scattering distributions by a Born iterative method,” J. Opt. Soc. Am. A 14, 325–341 (1997).
  14. H. Jiang, K. Paulsen, U. Osterberg, B. Pogue, and M. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A. 12, 253–266 (1995).
  15. X. Li, T. Durduran, A. Yodh, B. Chance, and D. N. Pattanayak, “Diffraction tomography for biomedical imaging with diffuse-photon density waves,” Opt. Lett. 22, 573–575 (1997).
  16. C. Matson and H. Liu, “Backpropagation in turbid media,” J. Opt. Soc. Am. A 16, 1254–1265 (1999).
  17. M. A. O’Leary, “Imaging with diffuse photon density waves,” Ph.D. dissertation (University of Pennsylvania, Philadelphia, Pa., 1996).
  18. K. Paulsen, P. Meaney, M. Moskowitz, and J. Sullivan, Jr., “A dual mesh scheme for finite element based reconstruction algorithms,” IEEE Trans. Med. Imaging 14, 504–514 (1995).
  19. S. Arridge and M. Schweiger, “Photon-measurement density functions. Part I: Analytical forms,” Appl. Opt. 34, 7395–7409 (1995).
  20. S. Arridge and M. Schweiger, “Photon-measurement density functions. II. Finite-element-method calculations,” Appl. Opt. 34, 8026–8037 (1995).
  21. Q. Zhu, T. Dunrana, M. Holboke, V. Ntziachristos, and A. Yodh, “Imager that combines near-infrared diffusive light and ultrasound,” Opt. Lett. 24, 1050–1052 (1999).
  22. Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, “Combined ultrasound and near infrared diffusive light imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665–678 (1999).
  23. Q. Zhu, E. Conant, and B. Chance, “Optical imaging as an adjunct to sonograph in differentiating benign from malignant breast lesions,” J. Biomed. Opt. 5(2), 229–236 (2000).
  24. Q. Zhu, N. G. Chen, D. Q. Piao, P. Y. Guo, and X. H. Ding, “Design of near-infrared imaging probe with the assistance of ultrasound localization,” Appl. Opt. 40, 3288–3303 (2001).
  25. M. Jholboke, B. J. Tromberg, X. Li, N. Shah, J. Fishkin, D. Kidney, J. Butler, B. Chance, and A. G. Yodh, “Three-dimensional diffuse optical mammography with ultrasound localization in human subject,” J. Biomed. Opt. 5(2), 237–247 (2000).
  26. W. Zhu, Y. Wang, and J. Zhang, “Total least-squares reconstruction with wavelets for optical tomography,” J. Opt. Soc. Am. A 15, 2639–2650 (1998).
  27. P. C. Li, W. Flax, E. S. Ebbini, and M. O’Donnell, “Blocked element compensation in phased array imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 40(4), 283–292 (1993).
  28. G. H. Golub, “Some modified matrix eigenvalue problems,” SIAM (Soc. Ind. Appl. Math.) Rev. 15, 318–334 (1973).
  29. H. Zonderland, E. G. Coerkamp, J. Hermans, M. J. van de Vijver, and A. E. van Voorthuisen, “Diagnosis of breast cancer: contribution of US as an adjunct to mammography,” Radiology 213, 413–422 (1999).
  30. T. M. Kolb, J. Lichy, and J. H. Newhouse, “Occult cancer in women with dense breast: detection with screening US-diagnostic yield and tumor characteristics,” Radiology 207, 191–199 (1998).

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