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Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 40, Iss. 7 — Mar. 1, 2001
  • pp: 1155–1164

Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths

Jan S. Dam, Carsten B. Pedersen, Torben Dalgaard, Paul Erik Fabricius, Prakasa Aruna, and Stefan Andersson-Engels  »View Author Affiliations


Applied Optics, Vol. 40, Issue 7, pp. 1155-1164 (2001)
http://dx.doi.org/10.1364/AO.40.001155


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Abstract

We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source–detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 × 7 calibration matrix of Intralipid–dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0–0.3/cm for the absorption coefficient and 6–16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements.

© 2001 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1580) Medical optics and biotechnology : Chemometrics
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

History
Original Manuscript: May 26, 2000
Revised Manuscript: December 7, 2000
Published: March 1, 2001

Citation
Jan S. Dam, Carsten B. Pedersen, Torben Dalgaard, Paul Erik Fabricius, Prakasa Aruna, and Stefan Andersson-Engels, "Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths," Appl. Opt. 40, 1155-1164 (2001)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-40-7-1155

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