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Applied Optics

Applied Optics


  • Vol. 41, Iss. 1 — Jan. 1, 2002
  • pp: 182–192

Skin lesion classification using oblique-incidence diffuse reflectance spectroscopic imaging

Mehrübe Mehrübeoğlu, Nasser Kehtarnavaz, Guillermo Marquez, Madeleine Duvic, and Lihong V. Wang  »View Author Affiliations

Applied Optics, Vol. 41, Issue 1, pp. 182-192 (2002)

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We discuss the use of a noninvasive in vivo optical technique, diffuse reflectance spectroscopic imaging with oblique incidence, to distinguish between benign and cancer-prone skin lesions. Various image features were examined to classify the images from lesions into benign and cancerous categories. Two groups of lesions were processed separately: Group 1 includes keratoses, warts versus carcinomas; and group 2 includes common nevi versus dysplastic nevi. A region search algorithm was developed to extract both one- and two-dimensional spectral information. A bootstrap-based Bayes classifier was used for classification. A computer-assisted tool was then devised to act as an electronic second opinion to the dermatologist. Our approach generated only one false-positive misclassification out of 23 cases collected for group 1 and two misclassifications out of 34 cases collected for group 2 under the worst estimation condition.

© 2002 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(110.0110) Imaging systems : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(300.0300) Spectroscopy : Spectroscopy

Original Manuscript: October 20, 2000
Revised Manuscript: May 7, 2001
Published: January 1, 2002

Mehrübe Mehrübeoğlu, Nasser Kehtarnavaz, Guillermo Marquez, Madeleine Duvic, and Lihong V. Wang, "Skin lesion classification using oblique-incidence diffuse reflectance spectroscopic imaging," Appl. Opt. 41, 182-192 (2002)

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