Ultrasound-Modulated Optical Tomography of Biological Tissue by Use of Contrast of Laser Speckles
Applied Optics, Vol. 41, Issue 28, pp. 6030-6035 (2002)
http://dx.doi.org/10.1364/AO.41.006030
Acrobat PDF (753 KB)
Abstract
Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated. An ultrasonic beam was focused into a biological-tissue sample to modulate the laser light passing through the ultrasonic column inside the tissue. The contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging. Variation in the speckle contrast reflected optical inhomogeneity in the tissue. With this technique, two-dimensional images of biological-tissue samples of as much as 25 mm thick were successfully obtained with a low-power laser. The technique was experimentally compared with speckle-contrast-based, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated.
© 2002 Optical Society of America
OCIS Codes
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
Citation
Jun Li, Geng Ku, and Lihong V. Wang, "Ultrasound-Modulated Optical Tomography of Biological Tissue by Use of Contrast of Laser Speckles," Appl. Opt. 41, 6030-6035 (2002)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-41-28-6030
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Related Journal Articles 
- Frequency-swept ultrasound-modulated optical tomography in biological tissue by use of parallel detection (OL)
- Theoretical and Experimental Studies of Ultrasound-Modulated Optical Tomography in Biological Tissue (AO)
- Methods for parallel-detection-based ultrasound-modulated optical tomography (AO)
- Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues (AO)
- Signal Dependence and Noise Source in Ultrasound-Modulated Optical Tomography (AO)
Related Conference Papers
- Compensated transillumination of a human hand
- Ultrasound-modulated optical tomography in biological tissue: Theoretical and experimental studies
- High resolution laser speckle contrast imaging of cerebral blood flow at microscopic scale during functional activation
- Calibration in laser speckle contrast imaging
- Benign versus malignant breast masses: Optical differentiation with US localization
OSA is a member of 