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Applied Optics

Applied Optics


  • Vol. 41, Iss. 28 — Oct. 1, 2002
  • pp: 6030–6035

Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles

Jun Li, Geng Ku, and Lihong V. Wang  »View Author Affiliations

Applied Optics, Vol. 41, Issue 28, pp. 6030-6035 (2002)

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Ultrasound-modulated optical tomography based on the measurement of laser-speckle contrast was investigated. An ultrasonic beam was focused into a biological-tissue sample to modulate the laser light passing through the ultrasonic column inside the tissue. The contrast of the speckle pattern formed by the transmitted light was found to depend on the ultrasonic modulation and could be used for imaging. Variation in the speckle contrast reflected optical inhomogeneity in the tissue. With this technique, two-dimensional images of biological-tissue samples of as much as 25 mm thick were successfully obtained with a low-power laser. The technique was experimentally compared with speckle-contrast-based, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated.

© 2002 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(120.6150) Instrumentation, measurement, and metrology : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

Original Manuscript: December 14, 2001
Revised Manuscript: April 18, 2002
Published: October 1, 2002

Jun Li, Geng Ku, and Lihong V. Wang, "Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles," Appl. Opt. 41, 6030-6035 (2002)

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