OSA's Digital Library

Applied Optics

Applied Optics


  • Vol. 41, Iss. 7 — Mar. 1, 2002
  • pp: 1462–1468

Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors

Thomas Johansson, Marcelo Soto Thompson, Maria Stenberg, Claes af Klinteberg, Stefan Andersson-Engels, Sune Svanberg, and Katarina Svanberg  »View Author Affiliations

Applied Optics, Vol. 41, Issue 7, pp. 1462-1468 (2002)

View Full Text Article

Enhanced HTML    Acrobat PDF (1354 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development. The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.

© 2002 Optical Society of America

OCIS Codes
(060.2310) Fiber optics and optical communications : Fiber optics
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(300.2530) Spectroscopy : Fluorescence, laser-induced

Original Manuscript: March 7, 2001
Revised Manuscript: August 20, 2001
Published: March 1, 2002

Thomas Johansson, Marcelo Soto Thompson, Maria Stenberg, Claes af Klinteberg, Stefan Andersson-Engels, Sune Svanberg, and Katarina Svanberg, "Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors," Appl. Opt. 41, 1462-1468 (2002)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. S. L. Marcus, “Photodynamic therapy of human cancer: clinical status, potential and needs,” in Future Directions and Applications in Photodynamic Therapy, C. J. Gomer, ed., Proc. SPIEIS-6, 5–56 (1990).
  2. L. I. Grossweiner, The Science of Phototherapy (CRC Press, Boca Raton, Fla., 1994).
  3. T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889–905 (1998). [CrossRef] [PubMed]
  4. J. C. Kennedy, R. H. Pottier, D. C. Pross, “Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience,” J. Photochem. Photobiol. B 6, 143–148 (1990). [CrossRef] [PubMed]
  5. J. C. Kennedy, R. H. Pottier, “Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy,” J. Photochem. Photobiol. B 14, 275–292 (1992). [CrossRef] [PubMed]
  6. K. Svanberg, T. Andersson, D. Killander, I. Wang, U. Stenram, S. Andersson-Engels, R. Berg, J. Johansson, S. Svanberg, “Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation,” Br. J. Dermatol. 130, 743–751 (1994). [CrossRef] [PubMed]
  7. Q. Peng, T. Warloe, K. Berg, J. Moan, M. Kongshaug, K.-E. Giercksky, J. M. Nesland, “5-aminolevulinic acid-based photodynamic therapy: clinical research and future challenges,” Cancer 79, 2282–2308 (1997). [CrossRef] [PubMed]
  8. I. Wang, B. Bauer, S. Andersson-Engels, S. Svanberg, K. Svanberg, “Photodynamic therapy utilising topical δ-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin,” Acta Ophthalmol. Scand. 77, 182–188 (1999). [CrossRef] [PubMed]
  9. I. Wang, N. Bendsoe, C. af Klinteberg, A. M. K. Enejder, S. Andersson-Engels, S. Svanberg, K. Svanberg, “Photodynamic therapy versus cryosurgery of basal cell carcinomas: results of a phase III randomized clinical trial,” Br. J. Dermatol. 144, 832–840 (2000). [CrossRef]
  10. T. J. Dougherty, R. E. Thoma, D. G. Boyle, K. R. Weishaupt, “Interstitial photoradiation therapy for primary solid tumors in pet cats and dogs,” Cancer Res. 41, 401–404 (1981). [PubMed]
  11. J. P. A. Marijnissen, J. A. C. Versteeg, W. M. Star, W. L. J. van Putten, “Tumor and normal response to interstitial photodynamic therapy of the rat R-1 rhabdomyosarcoma,” Int. J. Radiat. Oncol. Biol. Phys. 22, 963–972 (1992). [CrossRef]
  12. C. P. Lowdell, D. V. Ash, I. Driver, S. B. Brown, “Interstitial photodynamic therapy. Clinical experience with diffusing fibres in the treatment of cutaneous and subcutaneous tumours,” Br. J. Cancer 67, 1398–1403 (1993). [CrossRef] [PubMed]
  13. S. F. Purkiss, R. Dean, J. T. Allardice, M. Grahn, N. S. Williams, “An interstitial light delivery system for photodynamic therapy within the liver,” Lasers Med. Sci. 8, 253–257 (1993). [CrossRef]
  14. S. Svanberg, S. Andersson-Engels, R. Berg, J. Johansson, K. Svanberg, “System for laser treatments of tumours,” Swedish patent503408 (10June1996).
  15. A. M. K. Nilsson, R. Berg, S. Andersson-Engels, “Measurements of the optical properties of tissue in conjunction with photodynamic therapy,” Appl. Opt. 34, 4609–4619 (1995). [CrossRef] [PubMed]
  16. N. Ohlsson, O. Rylow, “Development of a multifibre system for interstitial photodynamic therapy of malignant tumours,” MSc thesis (Lund Institute of Technology, Lund, Sweden, LRAP-240, 1998).
  17. S. R. Arridge, M. Schweiger, M. Hiraoka, D. T. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299–309 (1993). [CrossRef] [PubMed]
  18. N. S. Ottosen, H. Petersson, Introduction to the Finite Element Method (Prentice Hall International, London, 1992).
  19. S. S. Rao, The Finite Element Method in Engineering (Pergamon, New York, 1989).
  20. G. Hedlund, H. O. Sjögren, “Induction of transplantation immunity to rat colon carcinoma isografts by implantation of intact fetal colon tissue,” Int. J. Cancer 26, 71–73 (1980). [CrossRef] [PubMed]
  21. J. Johansson, R. Berg, K. Svanberg, S. Svanberg, “Laser-induced fluorescence studies of normal and malignant tumour tissue of rat following intravenous injection of δ-amino levulinic acid,” Lasers Surg. Med. 20, 272–279 (1997). [CrossRef]
  22. C. af Klinteberg, M. Andreasson, O. Sandström, S. Andersson-Engels, S. Svanberg are preparing a manuscript to be called “Compact medical fluorosensor for minimally invasive tissue characterization.”
  23. T. Andersson, R. Berg, J. Johansson, D. Killander, K. Svanberg, S. Svanberg, Y. L. Yang, “Photodynamic therapy in interplay with fluorescence diagnostics in the treatment of human superficial malignancies,” in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, T. J. Dougherty, ed., Proc. SPIE1645, pp. 187–199 (1992). [CrossRef]
  24. K. T. V. Grattan, Z. Y. Zhang, Fiber Optic Fluorescence Thermometry (Chapman Hall, London, 1995).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited