A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development. The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.
© 2002 Optical Society of America
(060.2310) Fiber optics and optical communications : Fiber optics
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(300.2530) Spectroscopy : Fluorescence, laser-induced
Thomas Johansson, Marcelo Soto Thompson, Maria Stenberg, Claes af Klinteberg, Stefan Andersson-Engels, Sune Svanberg, and Katarina Svanberg, "Feasibility Study of a System for Combined Light Dosimetry and Interstitial Photodynamic Treatment of Massive Tumors," Appl. Opt. 41, 1462-1468 (2002)