OSA's Digital Library

Applied Optics

Applied Optics


  • Vol. 41, Iss. 7 — Mar. 1, 2002
  • pp: 1469–1475

Determination of glucose concentration in a scattering medium based on selected wavelengths by use of an overtone absorption band

Gilwon Yoon, Airat K. Amerov, Kye Jin Jeon, and Yoen-Joo Kim  »View Author Affiliations

Applied Optics, Vol. 41, Issue 7, pp. 1469-1475 (2002)

View Full Text Article

Enhanced HTML    Acrobat PDF (174 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A method and device for measuring glucose concentration in a scattering medium have been developed. A spectral range of 800–1800 nm is considered for wavelength selection because of its deeper penetration into biological tissue and the presence of a glucose absorption band. An algorithm based on selected wavelengths is proposed to minimize interference from other components. The optimal distance between the light source and the detector for diffuse reflectance measurement minimizes the influence of medium scattering. The proposed algorithm and measuring device are tested with a solution containing milk with added glucose. Glucose concentrations between 0 and 2000 mg/dl are determined with a correlation coefficient of 0.977. We also investigate the influence of concentration variations of other substances such as water, hemoglobin, albumin, and cholesterol when they are mixed in a scattering medium.

© 2002 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

Original Manuscript: April 17, 2001
Revised Manuscript: September 21, 2001
Published: March 1, 2002

Gilwon Yoon, Airat K. Amerov, Kye Jin Jeon, and Yoen-Joo Kim, "Determination of glucose concentration in a scattering medium based on selected wavelengths by use of an overtone absorption band," Appl. Opt. 41, 1469-1475 (2002)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. K. Robinson, “Blood analysis: noninvasive methods hover on horizon,” in Proceedings of Biophotonics International, May/June 1998 (Laurin, Pittsfield, Mass., 1998), pp. 48–52.
  2. M. R. Robinson, R. P. Eaton, D. M. Haaland, G. W. Koepp, E. V. Thomas, B. R. Stallard, P. L. Robinson, “Noninvasive glucose monitoring in diabetic patients: a preliminary evaluation,” Clin. Chem. 38, 1618–1622 (1992). [PubMed]
  3. U. A. Muller, B. Mertes, C. Fischbacher, K. U. Jageman, K. Danzer, “Noninvasive blood glucose monitoring by means of near infrared spectroscopy: methods for improving the reliability of the calibration models,” Int. J. Artif. Organs 20, 285–290 (1997).
  4. R. Marbach, T. H. Kochinsky, F. A. Gries, H. M. Heise, “Noninvasive blood glucose assay by near-infrared diffuse reflectance spectroscopy of the human inner lip,” Appl. Spectrosc. 47, 875–881 (1993). [CrossRef]
  5. J. T. Bruulsema, M. Essenpreis, L. Heinemann, J. E. Hayward, M. Berger, F. A. Gries, T. Koschinsky, J. Sandahl-Christiansen, H. Orskov, T. J. Farrell, M. S. Patterson, D. Bocker, “Detection of changes in blood glucose concentration in vivo with spatially resolved diffuse reflectance,” in Biomedical Optical Spectroscopy and Diagnostics, E. Sevick-Muraka, D. Benaron, eds., Vol. 3 of OSA Trends in Optics and Photonic Series (Optical Society of America, Washington, D.C., 1996), pp. 2–6.
  6. J. T. Bruulsema, J. E. Hayward, T. J. Farrell, M. S. Patterson, L. Heinemann, M. Berger, T. Kochinsky, J. Sandahl-Christiansen, H. Orskov, M. Essenpreis, G. Schmelzeisen-Redeker, D. Bocker, “Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient,” Opt. Lett. 22, 190–192 (1997). [CrossRef] [PubMed]
  7. M. A. Arnold, J. J. Burmeister, G. W. Small, “Phantom glucose calibration models from simulated noninvasive human near-infrared spectra,” Anal. Chem. 70, 1773–1781 (1990). [CrossRef]
  8. A. K. Amerov, T. V. Lisenko, N. M. Pokrasion, V. L. Strizhevskii, E. G. Sulima, “Determination of blood components by optical reflection spectra,” in International Conference on Holography, Correlation Optics, and Recording Materials, O. V. Angelsky, ed., Proc. SPIE2108, 521–527 (1993). [CrossRef]
  9. J. G. Webster, Design of Pulse Oximeter (Institute of Physics, London, 1997), Chaps. 1, 4, and 9.
  10. G. M. Hale, M. R. Querry, “Optical constants of water in the 200-nm to 200-µm wavelength region,” Appl. Opt. 12, 555–563 (1973). [CrossRef] [PubMed]
  11. T. J. Farrel, M. S. Patterson, B. C. Wilson, “A diffuse theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19, 879–888 (1992). [CrossRef]
  12. J. S. Maier, S. A. Walker, S. Fantini, A. Franceschini, E. Gratton, “Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissue in the near infrared,” Opt. Lett. 19, 2062–2064 (1994). [CrossRef] [PubMed]
  13. G. Yoon, S. A. Prahl, A. J. Welch, “Accuracy of the diffusion approximation and its similarity relations for laser irradiated biological media,” Appl. Opt. 28, 2250–2255 (1989). [CrossRef] [PubMed]
  14. K. J. Jeon, K. H. Lee, U. Kim, S.-H. Park, G. Yoon, H. S. Eom, E. Kim, “Measurement of the optical coefficients of multiple scattering media from time-resolved reflectance spectra,” J. Korean Phys. Soc. 32, 823–827 (1998).
  15. R. Cubeddu, M. Musolino, A. Pifferi, P. Taroni, G. Valentini, “Time-resolved reflectance: a systematic study for application to the optical characterization of tissues,” IEEE J. Quantum Electron. 30, 2421–2430 (1994). [CrossRef]
  16. R. C. Haskell, L. O. Svaasand, T. T. Tsay, T. C. Feng, M. S. McAdams, B. J. Tromberg, “Boundary condition for the diffusion equation in radiative transfer,” J. Opt. Soc. Am. A 11, 2727–2732 (1994). [CrossRef]
  17. S. Fantini, M. A. Francechini, J. B. Fishkin, B. Barbieri, E. Gratton, “Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode-based technique,” Appl. Opt. 33, 5204–5213 (1994). [CrossRef] [PubMed]
  18. G. Kumar, J. M. Schmitt, “Optical probe geometry for near-infrared spectroscopy of biological tissue,” Appl. Opt. 36, 2286–2293 (1997). [CrossRef] [PubMed]
  19. T. L. Troy, S. N. Thennadil, “Optical properties of human skin in the near-infrared wavelength range of 1000–2200 nm,” J. Biomed. Opt. 6, 167–176 (2001). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article

OSA is a member of CrossRef.

CrossCheck Deposited