OSA's Digital Library

Applied Optics

Applied Optics

APPLICATIONS-CENTERED RESEARCH IN OPTICS

  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 2881–2887

Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models

Yuich Fukui, Yusaku Ajichi, and Eiji Okada  »View Author Affiliations


Applied Optics, Vol. 42, Issue 16, pp. 2881-2887 (2003)
http://dx.doi.org/10.1364/AO.42.002881


View Full Text Article

Enhanced HTML    Acrobat PDF (275 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

In near-infrared spectroscopy and imaging, the sensitivity of the detected signal to brain activation and the volume of interrogated tissue are clinically important. Light propagation in adult and neonatal heads is strongly affected by the presence of a low-scattering cerebrospinal fluid layer. The effect of the heterogeneous structure of the head on light propagation in the adult brain is likely to be different from that in the neonatal brain because the thickness of the superficial tissues and the optical properties of the brain of the neonatal head are quite different from those of the adult head. In this study, light propagation in the two-dimensional realistic adult and neonatal head models, whose geometries are generated from a magnetic resonance imaging scan of the human heads, is predicted by Monte Carlo simulation. The sandwich structure, which is a low-scattering cerebrospinal fluid layer held between the high-scattering skull and gray matter, strongly affects light propagation in the brain of the adult head. The sensitivity of the absorption change in the gray matter is improved; however, the intensely sensitive region is confined to the shallow region of the gray matter. The high absorption of the neonatal brain causes a similar effect on light propagation in the head. The intensely sensitive region in the neonatal brain is confined to the gray matter; however, the spatial sensitivity profile penetrates into the deeper region of the white matter.

© 2003 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

History
Original Manuscript: September 1, 2002
Revised Manuscript: December 13, 2002
Published: June 1, 2003

Citation
Yuich Fukui, Yusaku Ajichi, and Eiji Okada, "Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models," Appl. Opt. 42, 2881-2887 (2003)
http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-42-16-2881


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. S. J. Matcher, C. E. Elwell, C. E. Cooper, M. Cope, D. T. Delpy, “Performance comparison of several published tissue near-infrared spectroscopy algorithms,” Anal. Biochem. 227, 54–68 (1995). [CrossRef]
  2. G. Gratton, M. Fabiani, D. Friedman, M. A. Franceschini, S. Fantini, P. Corballis, E. Gratton, “Rapid changes of optical parameters in the human brain during a tapping task,” J. Cog. Neurosci. 7, 446–456 (1995). [CrossRef]
  3. S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002). [CrossRef]
  4. A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, H. Koizumi, eds., “Spatial and temporal analysis of human motor activity using non-invasive NIR topography,” Med. Phys. 22, 1997–2005 (1995). [CrossRef] [PubMed]
  5. B. Chance, E. Anday, S. Nioka, S. Zhou, L. Hong, K. Worden, C. Li, T. Murray, Y. Ovetsky, D. Pidikiti, R. Thomas, “A novel method for fast imaging of brain function, non-invasively, with light,” Opt. Express 2, 411–423 (1998), http://www.opticsexpress.org . [CrossRef] [PubMed]
  6. J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, E. O. R. Reynolds, “Quantification of cerebral oxygenation and hemodynamics in sick newborn infants by near infrared spectrophotometry,” Lancet. ii, 1063–1066 (1986). [CrossRef]
  7. E. Okada, M. Firbank, M. Schweiger, S. R. Arridge, M. Cope, D. T. Delpy, “Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head,” Appl. Opt. 36, 21–31 (1997). [CrossRef] [PubMed]
  8. S. R. Arridge, M. Schweiger, “Photon-measurement density function. Part 2. Finite-element-method calculations,” Appl. Opt. 34, 8026–8037 (1995). [CrossRef] [PubMed]
  9. M. Firbank, E. Okada, D. T. Delpy, “A theoretical study of the signal contribution of regions of the adult head to near-infrared spectroscopy studies of visual evoked responses,” Neuroimage 8, 69–78 (1998). [CrossRef] [PubMed]
  10. D. A. Boas, J. P. Culver, J. J. Stott, A. K. Dunn, “Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head,” Opt. Express 10, 159–170 (2002), http://www.opticsexpress.org . [CrossRef] [PubMed]
  11. D. T. Delpy, M. Cope, P. van der Zee, S. R. Arridge, S. Wray, J. S. Watt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol. 33, 1443–1442 (1988). [CrossRef]
  12. M. Hiraoka, M. Firbank, M. Essenpreis, M. Cope, S. R. Arridge, P. van der Zee, D. T. Delpy, “A Monte Carlo investigation of optical pathlength in inhomogeneous tissue and its application to near-infrared spectroscopy,” Phys. Med. Biol. 38, 1859–1876 (1993). [CrossRef] [PubMed]
  13. C. R. Simpson, M. Kohl, M. Essenpreis, M. Cope, “Near-infrared optical properties of ex vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique,” Phys. Med. Biol. 43, 2465–2478 (1998). [CrossRef] [PubMed]
  14. M. Firbank, M. Hiraoka, M. Essenpreis, D. T. Delpy, “Measurement of the optical properties of the skull in the wavelength range 650–950 nm,” Phys. Med. Biol. 38, 503–510 (1993). [CrossRef] [PubMed]
  15. P. van der Zee, M. Essenpreis, D. T. Delpy, “Optical properties of brain tissue,” in Photon Migration and Imaging in Random Media and Tissues, Proc. SPIE1888, 454–465 (1993). [CrossRef]
  16. P. van der Zee, “Measurement and modelling of the optical properties of human tissue in the near infrared,” Ph.D. dissertation (University of London, London, 1992).
  17. E. Okada, D. T. Delpy, “Near infrared light propagation in an adult head model. 1. Modeling of low-level scattering in the cerebrospinal fluid layer,” Appl. Opt. 42, 2906–2914 (2003). [CrossRef] [PubMed]
  18. P. van der Zee, D. T. Delpy, “Simulation of the point spread function for light in tissue by Monte Carlo technique,” Adv. Exp. Med. Biol. 215, 179–191 (1987). [CrossRef]
  19. P. van der Zee, M. Cope, S. R. Arridge, M. Essenpreis, L. A. Potter, A. D. Edwards, J. S. Wyatt, D. C. McCormick, S. C. Roth, E. O. R. Reynolds, D. T. Delpy, “Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of inter optode spacing,” Adv. Exp. Med. Biol. 316, 143–153 (1992). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited