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Applied Optics

Applied Optics


  • Vol. 42, Iss. 16 — Jun. 1, 2003
  • pp: 2906–2914

Near-Infrared Light Propagation in an Adult Head Model. I. Modeling of Low-Level Scattering in the Cerebrospinal Fluid Layer

Eiji Okada and David T. Delpy  »View Author Affiliations

Applied Optics, Vol. 42, Issue 16, pp. 2906-2914 (2003)

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Adequate modeling of light propagation in a human head is important for quantitative near-infrared spectroscopy and optical imaging. The presence of a nonscattering cerebrospinal fluid (CSF) that surrounds the brain has been previously shown to have a strong effect on light propagation in the head. However, in reality, a small amount of scattering is caused by the arachnoid trabeculae in the CSF layer. In this study, light propagation in an adult head model with discrete scatterers distributed within the CSF layer has been predicted by Monte Carlo simulation to investigate the effect of the small amount of scattering caused by the arachnoid trabeculae in the CSF layer. This low scattering in the CSF layer is found to have little effect on the mean optical path length, a parameter that can be directly measured by a time-resolved experiment. However, the partial optical path length in brain tissue that relates the sensitivity of the detected signal to absorption changes in the brain is strongly affected by the presence of scattering within the CSF layer. The sensitivity of the near-infrared signal to hemoglobin changes induced by brain activation is improved by the effect of a low-scattering CSF layer.

© 2003 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

Eiji Okada and David T. Delpy, "Near-Infrared Light Propagation in an Adult Head Model. I. Modeling of Low-Level Scattering in the Cerebrospinal Fluid Layer," Appl. Opt. 42, 2906-2914 (2003)

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  1. R. Springett, M. Wylezinska, E. B. Cady, M. Cope, and D. T. Delpy, “Oxygen dependency of cerebral oxidative phosphorylation in newborn piglets,” J. Cereb. Blood Flow Metab. 20, 280–289 (2000).
  2. S. J. Matcher, C. E. Elwell, C. E. Cooper, M. Cope, and D. T. Delpy, “Performance comparison of several published tissue near-infrared spectroscopy algorithm,” Anal. Biochem. 227, 54–68 (1995).
  3. J. C. Hebden, S. R. Arridge, and D. T. Delpy, “Optical imaging in medicine. I. Experimental techniques,” Phys. Med. Biol. 42, 825–840 (1997).
  4. H. Koizumi, Y. Yamashita, A. Maki, T. Yamamoto, Y. Ito, H. Itagaki, and R. Kennan, “Higher-order brain function analysis by trans-cranial dynamic near-infrared spectroscopy imaging,” J. Biomed. Opt. 4, 403–413 (1999).
  5. B. Chance, E. Anday, S. Nioka, S. Zhou, L. Hong, K. Worden, C. Li, T. Murray, Y. Ovetsky, D. Pidikiti, and R. Thomas, “A novel method for fast imaging of brain function, non-invasively, with light,” Opt. Express 2, 411–423 (1998), http://www.opticsexpress.org.
  6. M. Firbank, S. R. Arridge, M. Schweiger, and D. T. Delpy, “An investigation of light transport through scattering bodies with nonscattering regions,” Phys. Med. Biol. 41, 767–783 (1996).
  7. E. Okada, M. Firbank, M. Schweiger, S. R. Arridge, M. Cope, and D. T. Delpy, “Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head,” Appl. Opt. 36, 21–31 (1997).
  8. M. Wolf, M. Keel, V. Dietz, K. von Siebenthal, H. U. Bucher, and O. Baenziger, “The influence of a clear layer on near-infrared spectrophotometry measurements using a liquid neonatal head phantom,” Phys. Med. Biol. 44, 1743–1753 (1999).
  9. H. Dehghani and D. T. Delpy, “Near-infrared spectroscopy of the adult head: effect of scattering and absorbing obstructions in the cerebrospinal fluid layer on light distribution in the tissue,” Appl. Opt. 39, 4721–4729 (2000).
  10. J. Ripoll, N. Nieto-Vesperinas, S. R. Arridge, and H. Dehghani, “Boundary conditions for light propagation in diffuse media with nonscattering regions,” J. Opt. Soc. Am. A 17, 1671–1681 (2000).
  11. K. Uludag, M. Kohl, J. Steinbrink, H. Obrig, and A. Villringer, “Cross talk in the Lambert-Beer calculation for near-infrared wavelength estimated by Monte Carlo simulation,” J. Biomed. Opt. 7, 51–59 (2002).
  12. A. H. Hielscher, R. E. Alcuffe, and R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissue,” Phys. Med. Biol. 43, 1285–1302 (1998).
  13. M. Firbank, E. Okada, and D. T. Delpy, “A theoretical study of the signal contribution of regions of the adult head to near-infrared spectroscopy studies of visual evoked responses,” Neuroimage 8, 69–78 (1998).
  14. S. R. Arridge, H. Dehghani, M. Schweiger, and E. Okada, “The finite element model for the propagation of light scattering media: a direct method for domain with nonscattering regions,” Med. Phys. 27, 252–264 (2000).
  15. M. B. Carpenter and J. Sutin, Human Neuroanatomy (Williams & Wilkins, Baltimore, Md., 1983).
  16. E. Okada and D. T. Delpy, “Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain,” in Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment, S. Andersson-Engels and J. G. Fujimoto, eds., Proc. SPIE 4160, 196–203 (2000).
  17. D. T. Delpy, M. Cope, P. van der Zee, S. R. Arridge, S. Wray, and J. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol. 33, 1433–1442 (1988).
  18. M. Hiraoka, M. Firbank, M. Essenpreis, M. Cope, S. R. Arridge, P. van der Zee, and D. T. Delpy, “A Monte Carlo investigation of optical pathlength in inhomogeneous tissue and its application to near-infrared spectroscopy,” Phys. Med. Biol. 38, 1859–1876 (1993).
  19. E. Okada, M. Firbank, and D. T. Delpy, “The effect of overlying tissue on the spatial sensitivity profile of near-infrared spectroscopy,” Phys. Med. Biol. 40, 2093–2108 (1995).
  20. C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, “Near-infrared optical properties of ex vivo human skin and subcutaneous tissue measured using the Monte Carlo inversion technique,” Phys. Med. Biol. 43, 2465–2478 (1998).
  21. M. Firbank, M. Hiraoka, M. Essenpreis, and D. T. Delpy, “Measurement of the optical properties of the skull in the wavelength range 650–950 nm,” Phys. Med. Biol. 38, 503–510 (1993).
  22. P. van der Zee, M. Essenpreis, and D. T. Delpy, “Optical properties of brain tissue,” in Photon Migration and Imaging in Random Media and Tissues, R. R. Alfano and B. Chance, eds., Proc. SPIE 1888, 454–465 (1993).
  23. B. C. Wilson, “A Monte Carlo model for the absorption and flux distribution of light in tissue,” Med. Phys. 10, 824–830 (1983).
  24. P. van der Zee and D. T. Delpy, “Simulation of the point spread function for light in tissue by a Monte Carlo technique,” Adv. Exp. Med. Biol. 215, 179–191 (1987).
  25. F. Bevilacqua, D. Piguet, P. Marquet, J. D. Gross, B. J. Tromberg, and C. Depeursinge, “In vivo local determination of tissue optical properties: applications to human brain,” Appl. Opt. 38, 4939–4950 (1999).

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