We will briefly review the present status of optical topography and then discuss the method of improving practicality, i.e., the signal-to-noise (S/N) ratio and the spatial resolution in observations of higher-order brain functions. The optimum wavelength pair improved the S/N ratio sixfold for deoxyhemoglobin, and new configurations of light irradiation and detection positions doubled the spatial resolution. We also report on developing application fields of optical topography. This modality will bridge the gap between natural sciences, neuroscience, and pedagogy, and show actual real-time brain activity.
© 2003 Optical Society of America
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media
Hideaki Koizumi, Tsuyoshi Yamamoto, Atsushi Maki, Yuichi Yamashita, Hiroki Sato, Hideo Kawaguchi, and Noriyoshi Ichikawa, "Optical Topography: Practical Problems and New Applications," Appl. Opt. 42, 3054-3062 (2003)